Intracholecystic papillary neoplasm of the gallbladder diagnosed during follow‑up of Menetrier's disease: A case report

Shimada,Shingo; Homma,Tomoki; Koyanagi,Kaname; Hamada,Kazuya; Miura,Chisako; Miura,Ichiro; Abe,Hironori

doi:10.3892/mco.2021.2396

Intracholecystic papillary neoplasm of the gallbladder diagnosed during follow‑up of Menetrier's disease: A case report

Authors:
- Shingo Shimada
- Tomoki Homma
- Kaname Koyanagi
- Kazuya Hamada
- Chisako Miura
- Ichiro Miura
- Hironori Abe
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Affiliations: Department of Surgery, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Hokkaido 080‑0805, Japan, Department of Pathology, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Hokkaido 080‑0805, Japan
Published online on: September 17, 2021 https://doi.org/10.3892/mco.2021.2396
Article Number: 233
Copyright: © Shimada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intracholecystic papillary neoplasm of the gallbladder (ICPN) is a type of intraductal papillary neoplasm of the bile duct that occurs in the gallbladder, and is a relatively newer concept. Therefore, there are few reports regarding ICPN. Menetrier's disease is a rare disease characterized by giant hypertrophy of the gastric folds that causes protein‑losing gastroenteropathy (PLG). Although Menetrier's disease is a known risk factor for gastric adenocarcinoma, the association between Menetrier's disease and malignancy other than a malignancy of the stomach is unclear. A 69‑year‑old man presented to the Hokkaido Social Work Association Obihiro Hospital with gallbladder tumours diagnosed by ultrasonography at a previous institution. In addition, he had previously been diagnosed with PLG due to Menetrier's disease. Abdominal contrast‑enhanced computed tomography (CT) revealed an irregular mass with a contrast effect at the fundus of the gallbladder on the free abdominal cavity side. Positron emission tomography‑CT showed a tumour with a standard uptake value (SUV) of 8.28 at the fundus of the gallbladder. Cholecystectomy and resection of the gallbladder bed were performed. Based on the microscopy findings, the patient was diagnosed with ICPN. Although he had postoperative ileus, he was discharged 14 days postoperatively due to improvement through conservative treatment. Such cases of ICPN complicated with Menetrier's disease are extremely rare. However, patients with Menetrier's disease may need to be screened for malignancies.

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