Mucoepidermoid carcinoma of the anterior lingual salivary gland: A rare case report

Gotoh,Shimpei; Nakasone,Toshiyuki; Matayoshi,Akira; Makishi,Shoko; Hirano,Fusahiro; Ntege,Edward H.; Shimizu,Yusuke; Nakamura,Hiroyuki

doi:10.3892/mco.2021.2444

Mucoepidermoid carcinoma of the anterior lingual salivary gland: A rare case report

Authors:
- Shimpei Gotoh
- Toshiyuki Nakasone
- Akira Matayoshi
- Shoko Makishi
- Fusahiro Hirano
- Edward H. Ntege
- Yusuke Shimizu
- Hiroyuki Nakamura
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Affiliations: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Ryukyu University, Nishihara, Okinawa 903‑0215, Japan, Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Ryukyu University, Nishihara, Okinawa 903‑0215, Japan
Published online on: November 14, 2021 https://doi.org/10.3892/mco.2021.2444
Article Number: 7
Copyright: © Gotoh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mucoepidermoid carcinomas (MECs) are rare head and neck malignant tumours that were originally considered to be benign. It has been estimated that ~20% of MECs in the major salivary glands, such as the parotid gland, and 50% in the several minor salivary glands found in the oral cavity, are malignant. The diagnosis of MECs is mainly based on ancillary and immunohistochemistry testing. However, owing to the difficulty in harvesting adequate material for histological examination, the histopathological diagnosis of intraoral MECs may be particularly challenging. We herein report a rare case of an 82‑year‑old patient who presented to the Department of Oral and Maxillofacial Surgery of Ryukyu University Hospital with complaints of a progressive swelling and pain in the ventral surface of the apex of the tongue. The patient had previously undergone needle biopsy and the histopathological analysis of the tumour suggested a diagnosis of irritation fibroma. To ensure a more accurate histopathological assessment, an incisional biopsy was performed, in addition to the haematological and radiological assessments. Examination of the obtained surgical specimen confirmed low‑grade MEC of the anterior lingual gland. The tumour was surgically excised, the patient healed uneventfully and no recurrence was detected on the regular 3‑year follow‑up. Although MECs are relatively more common in the minor salivary glands of the oral cavity, they are a rare occurrence in the anterior lingual gland. Therefore, adequate histological material should be surgically harvested to perform a complete evaluation of the morphology and cytology of the tumour and ensure the accuracy of diagnosis.

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