Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma

  • Authors:
    • Hiroki Sakai
    • Hiroyuki Kimura
    • Kanji Otsubo
    • Tomoyuki Miyazawa
    • Hideki Marushima
    • Koji Kojima
    • Motohiro Chosokabe
    • Naoki Furuya
    • Junki Koike
    • Kiyonaga Fujii
    • Toshihide Nishimura
    • Haruhiko Nakamura
    • Hisashi Saji
  • View Affiliations

  • Published online on: November 30, 2021     https://doi.org/10.3892/mco.2021.2455
  • Article Number: 22
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Abstract

Minichromosome maintenance (MCM) protein deregulation is associated with tumor formation, progression and malignant transformation. MCM2 is frequently expressed during premalignant lung cell proliferation and is a sensitive marker for the early detection of pulmonary malignant lesions. The present study was undertaken to investigate whether MCM2 expression is of clinical and prognostic value in patients who have undergone lung adenocarcinoma resection. Between January 2009 and December 2010, 102 consecutive patients underwent complete pulmonary resection (involving lobectomy or more extensive resection) for lung adenocarcinoma at St. Marianna Medical University Hospital (Kanagawa, Japan). Among those, 73 patients, who had a final pathological diagnosis of lung adenocarcinoma measuring ≥10 mm, were enrolled in the present study. High MCM2 expression was found in 35 patients (48.0%). Univariate analysis of the overall survival (OS) revealed that pathological stage and MCM2 expression were significant prognostic factors in lung adenocarcinoma (P<0.001 and P<0.002, respectively). Univariate analysis of the recurrence‑free survival (RFS), the significant prognostic factors included pathological stage, EGFR mutation status and MCM2 expression (P<0.001, P<0.034 and P<0.003, respectively). On multivariate survival analysis, high MCM2 expression and pathological stage II‑III were identified as independent strong prognostic factors (OS: HR=5.084, 95% CI: 1.715‑15.080, P=0.003; RFS: HR=2.761, 95% CI: 1.090‑6.998, P=0.032). Therefore, the findings of the present study demonstrated that MCM2 may serve as a potential biomarker and therapeutic target for lung adenocarcinoma.
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January-2022
Volume 16 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Sakai H, Kimura H, Otsubo K, Miyazawa T, Marushima H, Kojima K, Chosokabe M, Furuya N, Koike J, Fujii K, Fujii K, et al: Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. Mol Clin Oncol 16: 22, 2022.
APA
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K. ... Saji, H. (2022). Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. Molecular and Clinical Oncology, 16, 22. https://doi.org/10.3892/mco.2021.2455
MLA
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K., Chosokabe, M., Furuya, N., Koike, J., Fujii, K., Nishimura, T., Nakamura, H., Saji, H."Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma". Molecular and Clinical Oncology 16.1 (2022): 22.
Chicago
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K., Chosokabe, M., Furuya, N., Koike, J., Fujii, K., Nishimura, T., Nakamura, H., Saji, H."Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma". Molecular and Clinical Oncology 16, no. 1 (2022): 22. https://doi.org/10.3892/mco.2021.2455