Molecular characterization of human papillomavirus and mouse mammary tumor virus‑<em>like</em> infections in prostate cancer tissue and relevance with tumor characteristics

Abumsimir,Berjas; Mrabti,Mohammed; Laraqui,Abdelilah; Ameur,Ahmed; Koraishi,Saad Ibnsouda; Mzibri,Mohammed; Lamsisi,Maryame; Ennaji,Youssef; Almahasneh,Ihsan; Ennaji,Moulay Mustapha

doi:10.3892/mco.2022.2530

Molecular characterization of human papillomavirus and mouse mammary tumor virus‑like infections in prostate cancer tissue and relevance with tumor characteristics

Authors:
- Berjas Abumsimir
- Mohammed Mrabti
- Abdelilah Laraqui
- Ahmed Ameur
- Saad Ibnsouda Koraishi
- Mohammed Mzibri
- Maryame Lamsisi
- Youssef Ennaji
- Ihsan Almahasneh
- Moulay Mustapha Ennaji
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Affiliations: Pharmacological and Diagnostic Research Centre (PDRC), Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al‑Ahliyya Amman University (AAU), Amman 19328, Jordan, Research and Biosafety Laboratory, Mohammed V Construction Teaching Hospital, Rabat 6203, Morocco, Innovation Centre, LBM Laboratory, Faculty of Sciences and Techniques, Sidi Mohamed Ben Abdellah University‑Fes, Fes 1796, Morocco, Biology and Medical Research Unit, CNESTEN‑Rabat, Rabat 1382, Morocco, Team of Virology, Cancerology, and Medical Biotechnologies, Laboratory of Virology, Microbiology, Quality and Medical Biotechnologies/ETB, Faculty of Sciences and Techniques‑Mohammedia, Hassan II University of Casablanca, Mohammedia 20650, Morocco, Department of Biotechnology, Faculty of Science, University of Sharjah, Sharjah 27272, United Arab Emirates
Published online on: March 8, 2022 https://doi.org/10.3892/mco.2022.2530
Article Number: 97
Copyright: © Abumsimir et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The suspected roles of human Papillomavirus (HPV) and mouse mammary tumor virus (MMTV) infections in prostate tumor development were recently reported. To detect the frequency of HPV and MMTV‑like infections and clinical correlates of tumor characteristics, DNA samples from 50 men treated at Teaching Hospital of Rabat City (Morocco) between June 2017 and February 2019, were genotyped and confirmed by Sanger sequencing. Eight infections of HPV18 and two infections of MMTV‑like were detected, and 50% of patients were at a Gleason score of 6. A significant association between Gleason score and HPV or MMTV‑like infection was noted (P=0.0008); 90% of patients with viral infections presented with T1 and T2 pathological stage tumors. Yet, no significant differences were found between infected and noninfected men regarding other pathological parameters including prostate‑specific antigen (PSA), tumor histological stage, age at diagnosis and radical prostatectomy treatment (P=0.2179, 0.4702, 0.8101, and 0.9644, respectively). The molecular evolution of HPV and MMTV in comparison with previously aligned sequences was discussed. Our findings provide a highlight on the correlations between the clinical‑pathological parameters of prostate tumors and HPV and MMTV infections. Prospective studies with a wide sample size are needed for more statistical clarification of the association between viral infections with prostate tumor criteria.

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