Open Access

A clinical report on high‑dose cytarabine therapy for children with acute myeloid leukemia

  • Authors:
    • Ziliang Wu
    • Zelin Wu
    • Yawei Zou
    • Jingming Guan
    • Shangzhi Wu
    • Dehui Chen
  • View Affiliations

  • Published online on: October 6, 2022     https://doi.org/10.3892/mco.2022.2589
  • Article Number: 156
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite improvement in the long‑term survival rate following pediatric acute myeloid leukemia (AML), the rate remains low, even with optimal treatment. The present study reports the long‑term outcome of a small patient group treated with a single drug, high‑dose chemotherapy (HDCT) with cytarabine, including consolidation and maintenance therapy. RT‑PCR was conducted to assess 43 fusion genes, and after treatment, all cases have been followed up for 20 years (June 2002‑December 2020). With an 80% 5‑year survival rate, the results of this study highlight the possibility that pediatric AML can be reasonably effectively treated with relatively simple chemotherapy when necessary. HDCT is clinically safe, effective and relatively inexpensive. We propose that in the context of limited resources, HDCT should be considered as an alternative therapy for pediatric AML.
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November-2022
Volume 17 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Wu Z, Wu Z, Zou Y, Guan J, Wu S and Chen D: A clinical report on high‑dose cytarabine therapy for children with acute myeloid leukemia. Mol Clin Oncol 17: 156, 2022.
APA
Wu, Z., Wu, Z., Zou, Y., Guan, J., Wu, S., & Chen, D. (2022). A clinical report on high‑dose cytarabine therapy for children with acute myeloid leukemia. Molecular and Clinical Oncology, 17, 156. https://doi.org/10.3892/mco.2022.2589
MLA
Wu, Z., Wu, Z., Zou, Y., Guan, J., Wu, S., Chen, D."A clinical report on high‑dose cytarabine therapy for children with acute myeloid leukemia". Molecular and Clinical Oncology 17.5 (2022): 156.
Chicago
Wu, Z., Wu, Z., Zou, Y., Guan, J., Wu, S., Chen, D."A clinical report on high‑dose cytarabine therapy for children with acute myeloid leukemia". Molecular and Clinical Oncology 17, no. 5 (2022): 156. https://doi.org/10.3892/mco.2022.2589