AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in breast cancers

  • Authors:
    • Xiaobai Sun
    • Hong Chen
    • Shuling You
    • Zhikang Tian
    • Zhaoyu Wang
    • Fulin Liu
    • Wenyi Hu
    • Hao Zhang
    • Guoan Zhang
    • Hongli Zhao
    • Qingwei Guo
  • View Affiliations

  • Published online on: February 8, 2023     https://doi.org/10.3892/mco.2023.2618
  • Article Number: 22
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Abstract

Breast cancer (BC) is common worldwide. c‑Myc and AXL are both overexpressed in BC, promoting its progression. The present study aimed to investigate the role of AXL in c‑Myc expression in BC. Overexpression of AXL increased c‑Myc expression while knockdown of AXL decreased c‑Myc expression as determined by western blot analysis. Pharmaceutical inhibition of AXL also suppressed c‑Myc expression. AKT and ERK inhibitor LY294002 and U0126 suppressed c‑Myc expression, respectively. AXL overexpression which activates AKT and ERK signaling, upregulates c‑Myc expression, while kinase‑dead AXL which cannot activate AKT and ERK signaling, does not upregulate c‑Myc expression, emphasizing the important role of these two signaling pathways in c‑Myc upregulation. Finally, expression data of BC tissues from The Cancer Proteome Atlas displayed an association between AXL and c‑Myc. Taken together, the present study revealed that AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in BC.
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March-2023
Volume 18 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Sun X, Chen H, You S, Tian Z, Wang Z, Liu F, Hu W, Zhang H, Zhang G, Zhao H, Zhao H, et al: AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in breast cancers. Mol Clin Oncol 18: 22, 2023.
APA
Sun, X., Chen, H., You, S., Tian, Z., Wang, Z., Liu, F. ... Guo, Q. (2023). AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in breast cancers. Molecular and Clinical Oncology, 18, 22. https://doi.org/10.3892/mco.2023.2618
MLA
Sun, X., Chen, H., You, S., Tian, Z., Wang, Z., Liu, F., Hu, W., Zhang, H., Zhang, G., Zhao, H., Guo, Q."AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in breast cancers". Molecular and Clinical Oncology 18.3 (2023): 22.
Chicago
Sun, X., Chen, H., You, S., Tian, Z., Wang, Z., Liu, F., Hu, W., Zhang, H., Zhang, G., Zhao, H., Guo, Q."AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in breast cancers". Molecular and Clinical Oncology 18, no. 3 (2023): 22. https://doi.org/10.3892/mco.2023.2618