Open Access

Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10‑year period in Japan: The ROAD study 2005‑2015

  • Authors:
    • Izumi Inoue
    • Noriko Yoshimura
    • Toshiko Iidaka
    • Chiaki Horii
    • Shigeyuki Muraki
    • Hiroyuki Oka
    • Hiroshi Kawaguchi
    • Toru Akune
    • Takao Maekita
    • Kanae Mure
    • Kozo Nakamura
    • Sakae Tanaka
    • Masao Ichinose
  • View Affiliations

  • Published online on: May 19, 2023     https://doi.org/10.3892/mco.2023.2649
  • Article Number: 53
  • Copyright: © Inoue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Few large population‑based studies have examined the prevalence of atrophic gastritis (AG) and Helicobacter pylori infection in Japan. The purpose of the present study was to estimate the prevalence of AG and H. pylori infection by age, in addition to investigating their change rates from 2005 to 2016 in Japan using data from a large population‑based cohort. A total of 3,596 participants [1,690 in the baseline survey (2005‑2006) and 1,906 at the fourth survey (2015‑2016)] aged 18 to 97 years were included in the cohort. The prevalence of AG and H. pylori infection were examined at baseline and in the fourth survey based on serological tests for the H. pylori antibody titer and pepsinogen levels. The prevalence of AG and H. pylori infection were 40.1% (men, 44.1%; women, 38.0%) and 52.2% (men, 54.8%; women, 50.8%), respectively, at baseline. AG seropositivity rates showed a significant decrease from 40.1 to 25.8% in 10 years. H. pylori seropositivity rates decreased significantly from 52.2 to 35.5% in 10 years. Stratified for age, the prevalence of AG showed an increasing trend with age, whereas the prevalence of H. pylori infection increased with aging, except for in the elderly group, showing an inverted U‑shaped association. In this population‑based, cross‑sectional study with a 10‑year interval survey, the prevalence of AG and H. pylori infection decreased significantly. This change may influence the prevalence of H. pylori‑related diseases, including extra‑gastric disorders associated with H. pylori‑induced systemic subclinical inflammation and hypochlorhydria, such as colorectal neoplasia and arteriosclerosis.
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July-2023
Volume 19 Issue 1

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Spandidos Publications style
Inoue I, Yoshimura N, Iidaka T, Horii C, Muraki S, Oka H, Kawaguchi H, Akune T, Maekita T, Mure K, Mure K, et al: Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10‑year period in Japan: The ROAD study 2005‑2015. Mol Clin Oncol 19: 53, 2023.
APA
Inoue, I., Yoshimura, N., Iidaka, T., Horii, C., Muraki, S., Oka, H. ... Ichinose, M. (2023). Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10‑year period in Japan: The ROAD study 2005‑2015. Molecular and Clinical Oncology, 19, 53. https://doi.org/10.3892/mco.2023.2649
MLA
Inoue, I., Yoshimura, N., Iidaka, T., Horii, C., Muraki, S., Oka, H., Kawaguchi, H., Akune, T., Maekita, T., Mure, K., Nakamura, K., Tanaka, S., Ichinose, M."Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10‑year period in Japan: The ROAD study 2005‑2015". Molecular and Clinical Oncology 19.1 (2023): 53.
Chicago
Inoue, I., Yoshimura, N., Iidaka, T., Horii, C., Muraki, S., Oka, H., Kawaguchi, H., Akune, T., Maekita, T., Mure, K., Nakamura, K., Tanaka, S., Ichinose, M."Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10‑year period in Japan: The ROAD study 2005‑2015". Molecular and Clinical Oncology 19, no. 1 (2023): 53. https://doi.org/10.3892/mco.2023.2649