Open Access

Correlation between clinicopathological characteristics and the clinical prognosis of patients with gastroenteropancreatic neuroendocrine tumors

  • Authors:
    • Dongwei Fan
    • Xuanhe Li
    • Yousheng Yu
    • Xingliang Wang
    • Jun Fang
    • Cheng Huang
  • View Affiliations

  • Published online on: September 13, 2023     https://doi.org/10.3892/mco.2023.2681
  • Article Number: 85
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are one of the most common types of NETs, accounting for 65‑75% of all NETs. However, epidemiological characteristics of patients with GEP‑NETs in China are still lacking. The present retrospective study aimed to investigate the local epidemiology of GEP‑NETs and assess the prognostic factors in China. The data of 267 patients with GEP‑NETs who were admitted to the First Affiliated Hospital of Bengbu Medical College (Bengbu, China) and the Affiliated Hospital of West Anhui Health Vocational College (Lu'an, China) were retrospectively reviewed. The clinical and pathological characteristics of the patients, as well as follow‑up information, were collected, and the 5‑year survival rate was calculated. Kaplan‑Meier curves and log‑rank analysis were used to analyze the prognostic factors. The stomach (100/267; 37.5%) was the most common site of GEP‑NETs and the liver (25/39; 64.1%) was the most common metastatic site. A total of 166 (62.2%) and 219 (82.0%) patients had positive results for chromogranin A (CgA) and synaptophysin (Syn), respectively. The percentage of patients with tumor grade G1, G2 and G3 was 33.3, 21.0 and 45.7%, respectively. The 5‑year overall survival rate was 79.7%, and the age, tumor site, distant metastasis and tumor grading upon diagnosis were all prognostic factors. In conclusion, the present case series investigated the epidemiology and prognostic factors of GEP‑NETs in China. CgA and Syn could be used as diagnostic markers for NETs and the stomach was the most common primary tumor site. Lymph node metastasis, tumor site, distant metastasis and tumor grading were important prognostic factors.
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November-2023
Volume 19 Issue 5

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Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Fan D, Li X, Yu Y, Wang X, Fang J and Huang C: Correlation between clinicopathological characteristics and the clinical prognosis of patients with gastroenteropancreatic neuroendocrine tumors. Mol Clin Oncol 19: 85, 2023
APA
Fan, D., Li, X., Yu, Y., Wang, X., Fang, J., & Huang, C. (2023). Correlation between clinicopathological characteristics and the clinical prognosis of patients with gastroenteropancreatic neuroendocrine tumors. Molecular and Clinical Oncology, 19, 85. https://doi.org/10.3892/mco.2023.2681
MLA
Fan, D., Li, X., Yu, Y., Wang, X., Fang, J., Huang, C."Correlation between clinicopathological characteristics and the clinical prognosis of patients with gastroenteropancreatic neuroendocrine tumors". Molecular and Clinical Oncology 19.5 (2023): 85.
Chicago
Fan, D., Li, X., Yu, Y., Wang, X., Fang, J., Huang, C."Correlation between clinicopathological characteristics and the clinical prognosis of patients with gastroenteropancreatic neuroendocrine tumors". Molecular and Clinical Oncology 19, no. 5 (2023): 85. https://doi.org/10.3892/mco.2023.2681