Open Access

Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma

  • Authors:
    • Jinping Lu
    • Ting Kang
    • Zhenlin Zhang
  • View Affiliations

  • Published online on: September 22, 2023     https://doi.org/10.3892/mco.2023.2685
  • Article Number: 89
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aldo‑keto reductase family 1 member B10 (AKR1B10) is a potential marker of several types of cancer; however, the role of AKR1B10 in nasopharyngeal carcinoma (NPC) remains unclear. In the present study, AKR1B10 RNA‑seq data and clinical information were obtained from The Cancer Genome Atlas head and neck squamous cell carcinoma (HNSCC) database to evaluate the role of AKR1B10 in HNSCC. There was no statistically significant difference in the expression of AKR1B10 between HNSCC tissues and adjacent normal tissues, and high AKR1B10 expression was not associated with poor overall survival according to the public database. The present study further examined the role of AKR1B10 in patients with NPC using data obtained from the Gene Expression Omnibus database. Analysis of the GSE53819 and GSE61218 datasets showed that the there were no significant differences in the expression levels of AKR1B10 between NPC tissues and normal tissues. However, analysis of the GSE103611 dataset indicated that AKR1B10 may be associated with distance metastasis following radical treatment in NPC. Finally, serum samples from patients with NPC and healthy controls were collected and analyzed. The results revealed that AKR1B10 levels were significantly increased in samples from patients with NPC compared with those from healthy controls, and the area under the receiver operating characteristic curve was 0.909. In conclusion, unlike tissue AKR1B10 expression, serum AKR1B10 levels may be a promising biomarker for the diagnosis of NPC.
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November-2023
Volume 19 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Lu J, Kang T and Zhang Z: Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma. Mol Clin Oncol 19: 89, 2023
APA
Lu, J., Kang, T., & Zhang, Z. (2023). Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma. Molecular and Clinical Oncology, 19, 89. https://doi.org/10.3892/mco.2023.2685
MLA
Lu, J., Kang, T., Zhang, Z."Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma". Molecular and Clinical Oncology 19.5 (2023): 89.
Chicago
Lu, J., Kang, T., Zhang, Z."Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma". Molecular and Clinical Oncology 19, no. 5 (2023): 89. https://doi.org/10.3892/mco.2023.2685