Epidemiology of gastric cancer in Saudi Arabia from 2004 to 2017

Alghamdi,Ibrahim G.

doi:10.3892/mco.2023.2689

Epidemiology of gastric cancer in Saudi Arabia from 2004 to 2017

Authors:
- Ibrahim G. Alghamdi
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Affiliations: Public Health Department, College of Applied Medical Sciences, University of AL‑Baha, AL Baha 65527, Kingdom of Saudi Arabia
Published online on: October 4, 2023 https://doi.org/10.3892/mco.2023.2689
Article Number: 93
Copyright: © Alghamdi . This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC), a prevalent disease which globally affects both men and women, was predicted by the International Agency for Research on Cancer in 2020 to have an age‑standardized incidence rate (ASIR) in Saudi Arabia of 2.7 per 100,000 individuals for all ages and sexes (ranked 15th), and an age‑standardized mortality rate of 2.1 per 100,000 individuals (ranked 12th). The present retrospective study aimed to investigate the prevalence of GC across all administrative regions in Saudi Arabia. Specifically, the present study sought to examine the incidence of diagnosed cases, age‑specific incidence rates, crude incidence rates (CIRs) and ASIRs adjusted for age, year and region. To meet this aim, this retrospective descriptive epidemiological analysis was conducted on all cases of GC recorded in the Saudi Cancer Registry (SCR) between January 2004 and December 2017. The collected data were subjected to a range of statistical analyses (using SPSS version 20.0), including descriptive analyses, independent sample t‑tests, the Kruskal‑Wallis test and sex ratio analysis. In the SCR, a total of 4,066 cases of GC were recorded between 2004 and 2017. The regions with the highest overall ASIRs of GC for both men and women were found to be Riyadh, Najran and the Eastern Region, with rates ranging from 2.2‑4.0 per 100,000 individuals. Conversely, Jazan had the lowest ASIRs, with rates of 1.5 and 0.5 per 100,000 individuals for men and women, respectively. The overall ASIRs of GC were found to be significantly higher in men compared with women, with a ratio of 2.8 per 100,000 individuals (P<0.05). In conclusion, the present study has revealed that, between 2004 and 2017, there was a slight decrease in the values of both CIR and ASIR of GC in Saudi Arabia.

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1	Machlowska J, Baj J, Sitarz M, Maciejewski R and Sitarz R: Gastric cancer: Epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Ici. 21(4012)2020.PubMed/NCBI View Article : Google Scholar
2	Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010.PubMed/NCBI View Article : Google Scholar
3	Mukkamalla SKR, Recio-Boiles A and Babiker HM: Gastric cancer. In: StatPearls (Internet). StatPearls Publishing, Treasure Island, FL, 2022.
4	Ang T and Fock KM: Clinical epidemiology of gastric cancer. Singapore Med J. 55:621–628. 2014.PubMed/NCBI View Article : Google Scholar
5	Ferro A, Peleteiro B, Malvezzi M, Bosetti C, Bertuccio P, Levi F, Negri E, La Vecchia C and Lunet N: Worldwide trends in gastric cancer mortality (1980-2011), with predictions to. 2015, and incidence by subtype. Eur J Cancer. 50:1330–1344. 2014.PubMed/NCBI View Article : Google Scholar
6	Edwards BK, Noone AM, Mariotto AB, Simard EP, Boscoe FP, Henley SJ, Jemal A, Cho H, Anderson RN, Kohler BA, et al: Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer. 120:1290–1314. 2014.PubMed/NCBI View Article : Google Scholar
7	Kaneko S and Yoshimura T: Time trend analysis of gastric cancer incidence in Japan by histological types, 1975-1989. Br J Cancer. 84:400–405. 2001.PubMed/NCBI View Article : Google Scholar
8	American Cancer Society. Key statistics about stomach cancer. American Cancer Society, Atlanta, GA, 2022. https://www.cancer.org/cancer/stomach-cancer/about/key-statistics.html. Accessed September 20, 2022.
9	International Agency for Research on Cancer (IARC): GLOBOCAN. Maps: Section for Cancer Incidence and Mortality. IARC, Lyon, 2020. https://gco.iarc.fr/today/home. Accessed September 20, 2020.
10	Saudi Cancer Registry. Cancer Incidence Report Saudi Arabia 2017. Saudi Cancer Registry, Riyadh, 2017.
11	Kong X, Wang JL, Chen HM and Fang JY: Comparison of the clinicopathological characteristics of young and Elderly patients with gastric carcinoma: A meta analysis. J Surg Oncol. 106:346–352. 2012.PubMed/NCBI View Article : Google Scholar
12	Takatsu Y, Hiki N, Nunobe S, Ohashi M, Honda M, Yamaguchi T, Nakajima T and Sano T: Clinicopathological features of gastric cancer in young patients. Gastric Cancer. 19:472–478. 2015.PubMed/NCBI View Article : Google Scholar
13	Milne AN, Sitarz R, Carvalho R, Carneiro F and Offerhaus GJ: Early onset gastric cancer: On the road to unraveling gastric carcinogenesis. Curr Mol Med. 7:15–28. 2007.PubMed/NCBI View Article : Google Scholar
14	Forman D and Burley V: Gastric cancer: Global pattern of the disease and an overview of environmental risk factors. Best Pract Res Clin Gastroenterol. 20:633–649. 2006.PubMed/NCBI View Article : Google Scholar
15	Suryawala K, Soliman D, Mutyala M, Nageeb S, Boktor M, Seth A, Aravantagi A, Sheth A, Morris J, Jordan P, et al: Gastric cancer in women: A regional health-center seven year retrospective study. World J Gastroenterol. 21:7805–7813. 2015.PubMed/NCBI View Article : Google Scholar
16	Rawla P and Barsouk A: Epidemiology of gastric cancer: Global trends, risk factors and prevention. Prz Gastroenterol. 14:26–38. 2019.PubMed/NCBI View Article : Google Scholar
17	Yang D, Hendifar A, Lenz C, Togawa K, Lenz F, Lurje G, Pohl A, Winder T, Ning Y, Groshen S and Lenz HJ: Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity. J Gastrointest Oncol. 2:77–84. 2011.PubMed/NCBI View Article : Google Scholar
18	Chen C, Gong X, Yang X, Shang X, Du Q, Liao Q, Xie R, Chen Y and Xu J: The roles of estrogen and estrogen receptors in gastrointestinal disease (review). Oncol Lett. 18:5673–5680. 2019.PubMed/NCBI View Article : Google Scholar
19	National Cancer Institute (NCI): Cancer of the stomach-cancer stat facts. NCI, Bethesda, MD, 2022. https://seer.cancer.gov/statfacts/html/stomach.html. Retrieved September 26, 2022.
20	Sitarz R, Skierucha M, Mielko J, Offerhaus GJA, Maciejewski R and Polkowski WP: Gastric cancer: Epidemiology, prevention, classification, and treatment. Cancer Manag Res. 10:239–248. 2018.PubMed/NCBI View Article : Google Scholar
21	Lombe DC, Mwaba CK, Msadabwe SC, Banda L, Mwale M, Pupwe G, Kamfwa P, Kanduza M, Munkupa H, Maliti B, et al: Zambia's national cancer centre response to the COVID-19 pandemic-an opportunity for improved care. Ecancermedicalscience. 14(1051)2020.PubMed/NCBI View Article : Google Scholar
22	Kartik A, Garg D and Singh RB: Implications of reduced health care services for cancer patients in India and similar resource-limited health care systems during COVID-19 pandemic. Asia Pac J Public Health. 32:287–288. 2020.PubMed/NCBI View Article : Google Scholar
23	Pulumati A, Pulumati A, Dwarakanath BS, Verma A and Papineni RVL: Technological advancements in cancer diagnostics: Improvements and limitations. Cancer Rep (Hoboken). 6(e1764)2023.PubMed/NCBI View Article : Google Scholar