Open Access

Albumin‑bilirubin grade is an independent prognostic factor for small lung cell cancer

  • Authors:
    • Shicheng Liu
    • Qingtao Zhao
    • Zengming Wang
    • Bin Zhao
    • Xiaopeng Zhang
  • View Affiliations

  • Published online on: December 15, 2023     https://doi.org/10.3892/mco.2023.2710
  • Article Number: 12
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Albumin‑bilirubin (ALBI) grade was first described in 2015 as an indicator of liver dysfunction in patients with hepatocellular carcinoma. ALBI grade has been reported to have prognostic value in several malignancies including non‑small cell lung cancer (NSCLC). The present study aimed to explore the prognostic impact of ALBI grade in patients with small cell lung cancer (SCLC). It retrospectively analyzed 135 patients with SCLC treated at Hebei General Hospital between April 2015 and August 2021. Patients were divided into two groups according to the cutoff point of ALBI grade determined by the receiver operating characteristic (ROC) curve: Group 1 with pre‑treatment ALBI grade ≤‑2.55 for an improved hepatic reserve and group 2 with ALBI grade >‑2.55. Kaplan‑Meier and Cox regression analysis were performed to assess the potential prognostic factors associated with progression free survival (PFS) and overall survival (OS). Propensity score matching (PSM) was applied to eliminate the influence of confounding factors. PFS and OS (P<0.001) were significantly improved in group 1 compared with in group 2. Multivariate analysis revealed that sex (P=0.024), surgery (P=0.050), lactate dehydrogenase (LDH; P=0.038), chemotherapy (P=0.038) and ALBI grade (P=0.028) are independent risk factors for PFS and that surgery (P=0.013), LDH (P=0.039), chemotherapy (P=0.009) and ALBI grade (P=0.013) are independent risk factors for OS. After PSM, ALBI grade is an independent prognostic factor of PFS (P=0.039) and OS (P=0.007). It was concluded that ALBI grade was an independent prognostic factor in SCLC.
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February-2024
Volume 20 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Liu S, Zhao Q, Wang Z, Zhao B and Zhang X: Albumin‑bilirubin grade is an independent prognostic factor for small lung cell cancer. Mol Clin Oncol 20: 12, 2024.
APA
Liu, S., Zhao, Q., Wang, Z., Zhao, B., & Zhang, X. (2024). Albumin‑bilirubin grade is an independent prognostic factor for small lung cell cancer. Molecular and Clinical Oncology, 20, 12. https://doi.org/10.3892/mco.2023.2710
MLA
Liu, S., Zhao, Q., Wang, Z., Zhao, B., Zhang, X."Albumin‑bilirubin grade is an independent prognostic factor for small lung cell cancer". Molecular and Clinical Oncology 20.2 (2024): 12.
Chicago
Liu, S., Zhao, Q., Wang, Z., Zhao, B., Zhang, X."Albumin‑bilirubin grade is an independent prognostic factor for small lung cell cancer". Molecular and Clinical Oncology 20, no. 2 (2024): 12. https://doi.org/10.3892/mco.2023.2710