Open Access

Ailanthone induces autophagy and ferroptosis in non‑small cell lung cancer Lewis cells

  • Authors:
    • Hongbin Yang
    • Xiaotong Zhang
    • Yanjie Lu
    • Xin Wang
    • Zhengxin Zhang
    • Hailan Xu
    • Fan Li
    • Qianhui Chen
    • Yiying Bai
    • Xinyu Bai
    • Li Zhang
    • Lei Liu
  • View Affiliations

  • Published online on: February 5, 2024     https://doi.org/10.3892/mco.2024.2723
  • Article Number: 25
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ailanthone (AIL), a monomer derived from ailanthus in Chinese medicine, has been demonstrated to have antitumor effects, albeit the underlying mechanism is unknown. Autophagy and ferroptosis are two modes of cell death that have been championed as potential mechanisms implicated in the antitumor effects of various drugs. The present study demonstrated that AIL effectively suppresses the Lewis cell proliferation in non‑small cell lung cancer using MTT and colony formation assays. Autophagy and ferroptosis were verified using western blotting, immunofluorescence and ferroptosis detection. Additionally, the findings revealed that regulating the AMPK/mTOR/p70S6k signaling pathway may be the underlying mechanism for the antitumor effect of AIL. The present study established a theoretical foundation for further research into the utilization of AIL as a novel antitumor approach.
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March-2024
Volume 20 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Yang H, Zhang X, Lu Y, Wang X, Zhang Z, Xu H, Li F, Chen Q, Bai Y, Bai X, Bai X, et al: Ailanthone induces autophagy and ferroptosis in non‑small cell lung cancer Lewis cells. Mol Clin Oncol 20: 25, 2024.
APA
Yang, H., Zhang, X., Lu, Y., Wang, X., Zhang, Z., Xu, H. ... Liu, L. (2024). Ailanthone induces autophagy and ferroptosis in non‑small cell lung cancer Lewis cells. Molecular and Clinical Oncology, 20, 25. https://doi.org/10.3892/mco.2024.2723
MLA
Yang, H., Zhang, X., Lu, Y., Wang, X., Zhang, Z., Xu, H., Li, F., Chen, Q., Bai, Y., Bai, X., Zhang, L., Liu, L."Ailanthone induces autophagy and ferroptosis in non‑small cell lung cancer Lewis cells". Molecular and Clinical Oncology 20.3 (2024): 25.
Chicago
Yang, H., Zhang, X., Lu, Y., Wang, X., Zhang, Z., Xu, H., Li, F., Chen, Q., Bai, Y., Bai, X., Zhang, L., Liu, L."Ailanthone induces autophagy and ferroptosis in non‑small cell lung cancer Lewis cells". Molecular and Clinical Oncology 20, no. 3 (2024): 25. https://doi.org/10.3892/mco.2024.2723