Open Access

Wnt signaling and tumors (Review)

  • Authors:
    • Huaishi Wang
    • Lihai Zhang
    • Chao Hu
    • Hui Li
    • Mingyan Jiang
  • View Affiliations

  • Published online on: May 15, 2024     https://doi.org/10.3892/mco.2024.2743
  • Article Number: 45
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Wnt signaling is a highly conserved evolutionary pathway that plays a key role in regulation of embryonic development, as well as tissue homeostasis and regeneration. Abnormalities in Wnt signaling are associated with tumorigenesis and development, leading to poor prognosis in patients with cancer. However, the pharmacological effects and mechanisms underlying Wnt signaling and its inhibition in cancer treatment remain unclear. In addition, potential side effects of inhibiting this process are not well understood. Therefore, the present review outlines the role of Wnt signaling in tumorigenesis, development, metastasis, cancer stem cells, radiotherapy resistance and tumor immunity. The present review further identifies inhibitors that target Wnt signaling to provide a potential novel direction for cancer treatment. This may facilitate early application of safe and effective drugs targeting Wnt signaling in clinical settings. An in‑depth understanding of the mechanisms underlying inhibition of Wnt signaling may improve the prognosis of patients with cancer.
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July-2024
Volume 21 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Wang H, Zhang L, Hu C, Li H and Jiang M: Wnt signaling and tumors (Review). Mol Clin Oncol 21: 45, 2024
APA
Wang, H., Zhang, L., Hu, C., Li, H., & Jiang, M. (2024). Wnt signaling and tumors (Review). Molecular and Clinical Oncology, 21, 45. https://doi.org/10.3892/mco.2024.2743
MLA
Wang, H., Zhang, L., Hu, C., Li, H., Jiang, M."Wnt signaling and tumors (Review)". Molecular and Clinical Oncology 21.1 (2024): 45.
Chicago
Wang, H., Zhang, L., Hu, C., Li, H., Jiang, M."Wnt signaling and tumors (Review)". Molecular and Clinical Oncology 21, no. 1 (2024): 45. https://doi.org/10.3892/mco.2024.2743