Open Access

Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report

  • Authors:
    • Koji Kameyama
    • Kosuke Mizutani
    • Tetsuya Yamada
    • Seiji Sugiyama
    • Shingo Kamei
    • Shigeaki Yokoi
    • Kengo Matsunaga
    • Koseki Hirade
    • Yasutaka Kato
    • Hiroshi Nishihara
    • Satoshi Ishihara
    • Takashi Deguchi
  • View Affiliations

  • Published online on: June 20, 2024     https://doi.org/10.3892/mco.2024.2753
  • Article Number: 55
  • Copyright: © Kameyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Urothelial carcinoma of the bladder with osteoclast‑like giant cells (UCOGCs) is rare among the subtypes of poorly differentiated urothelial carcinoma. Its clinical significance and optimal treatment are unknown, and few reports on genomic analysis of UCOGCs have been reported. Detailed analysis including genetic analysis for rare type variants of cancer could be a foothold for further research. The present case describes the case of a 75‑year‑old man who presented with a non‑papillary bladder tumor 56 mm in diameter showing gross hematuria and pain on voiding. Following transurethral resection of the bladder tumor, the pathological diagnosis was invasive UCOGCs. Neoadjuvant chemotherapy and radical cystectomy were performed with the resected tumor pathologically diagnosed as invasive UCOGCs, high grade, pT3b, pN1. The present study also analyzed the genomic features using a cancer panel test. The panel test noted six gene alterations (PIK3CA p.E542K, HRAS p.G13R, ARAF copy number amplification, CDKN2A copy number loss, TP53 p.E285V, ARID1A p.S90Pfs*11) and telomerase reverse transcriptase (TERT) promoter variant. Accumulation of knowledge from molecular‑based testing is anticipated to determine precise treatment for rare cancer.
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August-2024
Volume 21 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Kameyama K, Mizutani K, Yamada T, Sugiyama S, Kamei S, Yokoi S, Matsunaga K, Hirade K, Kato Y, Nishihara H, Nishihara H, et al: Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report. Mol Clin Oncol 21: 55, 2024
APA
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S. ... Deguchi, T. (2024). Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report. Molecular and Clinical Oncology, 21, 55. https://doi.org/10.3892/mco.2024.2753
MLA
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S., Matsunaga, K., Hirade, K., Kato, Y., Nishihara, H., Ishihara, S., Deguchi, T."Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report". Molecular and Clinical Oncology 21.2 (2024): 55.
Chicago
Kameyama, K., Mizutani, K., Yamada, T., Sugiyama, S., Kamei, S., Yokoi, S., Matsunaga, K., Hirade, K., Kato, Y., Nishihara, H., Ishihara, S., Deguchi, T."Genomic analysis of bladder urothelial carcinoma with osteoclast‑like giant cells: A case report". Molecular and Clinical Oncology 21, no. 2 (2024): 55. https://doi.org/10.3892/mco.2024.2753