Association between body mass index combined with high-sensitivity C-reactive protein and the risk of postmenopausal breast cancer: A prospective cohort study

Jiang,Runxue; Shen,Jianglun; Wang,Xia; Chen,Shuohua; Wu,Shouling; Cai,Haifeng

doi:10.3892/mco.2024.2762

Association between body mass index combined with high-sensitivity C-reactive protein and the risk of postmenopausal breast cancer: A prospective cohort study

Authors:
- Runxue Jiang
- Jianglun Shen
- Xia Wang
- Shuohua Chen
- Shouling Wu
- Haifeng Cai
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Affiliations: Department of Oncology Surgery, Tangshan People's Hospital, Tangshan, Hebei 063000, P.R. China, Department of Gynaecology, Tangshan Hongci Hospital, Tangshan, Hebei 063000, P.R. China, Health Department of Kailuan (Group), Kailuan General Hospital, Tangshan, Hebei 063000, P.R. China
Published online on: July 12, 2024 https://doi.org/10.3892/mco.2024.2762
Article Number: 64
Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to assess the risk of postmenopausal breast cancer in women based on a combination of body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) levels. A total of 20,400 participants were investigated as part of the ‘Kailuan Study’ clinical trial. Participants were classified into four groups based on BMI (BMI ≥24 or <24 kg/m²) and hs-CRP level (hs-CRP ≥3 or <3 mg/l). Cox proportional hazards models were used to evaluate the association between the combination of BMI and hs-CRP and the risk of postmenopausal breast cancer. A total of 19,540 participants met the inclusion criteria. The median follow-up time was 14.97 years, with a cumulative follow-up period of 283,599.43 person-years. Among the participants, 269 individuals were diagnosed with postmenopausal breast cancer. Individuals with a high BMI (BMI ≥24 kg/m²) and a high hs-CRP level (hs-CRP ≥3 mg/) had a greater risk of postmenopausal breast cancer compared with individuals with a low BMI (BMI <24 kg/m²) and a low hs-CRP level (<3 mg/l) (hazard ratio, 1.75; 95% confidence interval, 1.25-2.47). The sensitivity analysis showed findings consistent with the primary results. In conclusion, the combination of high BMI and high hs-CRP level is associated with an increased risk of postmenopausal breast cancer. The present study is part of the Kailuan Study. Trial registration number: ChiCTRTNCR11001489 (Chinese Clinical Trial Registry, https://www.chictr.org.cn/showproj.html?proj=8050). Date of registration: 19/07/2015.

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