Open Access

Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report

  • Authors:
    • Marlies Maly
    • Lieve Vanwalleghem
    • Anja Van Den Eeckhaut
    • Vincent De Wilde
  • View Affiliations

  • Published online on: September 30, 2024     https://doi.org/10.3892/mco.2024.2786
  • Article Number: 88
  • Copyright: © Maly et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The diagnostic work‑up of cancer of unknown primary (CUP) is a challenging task; in addition, only a little data on BRAF targeting in CUP are currently available. Traditionally, the identification of favourable and unfavourable CUP subsets directs the choice of treatment. The present article reports the case of a 50‑year‑old male patient presenting with a BRAF‑mutated CUP, a rare and generally unfavourable subset. Based on imaging, immunohistochemistry and a high value of carbohydrate antigen 19‑9, an upper gastrointestinal profile was initially presumed. After disease progression on treatment with a first‑line platinum‑based doublet chemotherapy, a significant response was documented after treatment with the BEACON combination. The present case report highlighted the paradigm shift in diagnosis and treatment of CUP from a histology‑based approach to molecular profiling with the introduction of precision medicine.
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December-2024
Volume 21 Issue 6

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Spandidos Publications style
Maly M, Vanwalleghem L, Van Den Eeckhaut A and De Wilde V: Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report. Mol Clin Oncol 21: 88, 2024.
APA
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., & De Wilde, V. (2024). Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report. Molecular and Clinical Oncology, 21, 88. https://doi.org/10.3892/mco.2024.2786
MLA
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., De Wilde, V."Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report". Molecular and Clinical Oncology 21.6 (2024): 88.
Chicago
Maly, M., Vanwalleghem, L., Van Den Eeckhaut, A., De Wilde, V."Cancer of unknown primary and BRAF V600E meeting the BEACON combination: A case report". Molecular and Clinical Oncology 21, no. 6 (2024): 88. https://doi.org/10.3892/mco.2024.2786