Open Access

Simultaneous intravascular large B‑cell lymphoma and papillary thyroid carcinoma: A case report

  • Authors:
    • Jinxiang Liang
    • Jie Li
    • Bingjie Li
    • Jie Yang
    • Qiang Wei
    • Yan Li
  • View Affiliations

  • Published online on: March 11, 2025     https://doi.org/10.3892/mco.2025.2833
  • Article Number: 38
  • Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intravascular large B‑cell lymphoma (IVLBCL) is a rare subtype of B‑cell lymphoma. The concurrence of IVLBCL and papillary thyroid carcinoma (PTC) is extremely rare. A 63‑year‑old woman was diagnosed with double‑expression IVLBCL that presented as a hemophagocytic syndrome, complicated by PTC. IVLBCL was diagnosed by positron emission tomography/computed tomography (PET/CT) before bone marrow biopsy. Immunofixation electrophoresis displayed M proteins positive and IgG kappa light chains that the differential diagnosis should have included both multiple myeloma and IVLBCL. After treatment with rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone and etoposide, the patient's cytokine titres and other laboratory indicators returned to normal. PET/CT showed that complete remission had been achieved. She has been taking zanubrutinib for 1.5 years and remains in remission. This is a report of a patient with hemophagocytic syndrome‑associated IVLBCL with CCND1 and DNMT3A gene mutations combined with PTC and describes changes before and after treatment.
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May-2025
Volume 22 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Liang J, Li J, Li B, Yang J, Wei Q and Li Y: Simultaneous intravascular large B‑cell lymphoma and papillary thyroid carcinoma: A case report. Mol Clin Oncol 22: 38, 2025.
APA
Liang, J., Li, J., Li, B., Yang, J., Wei, Q., & Li, Y. (2025). Simultaneous intravascular large B‑cell lymphoma and papillary thyroid carcinoma: A case report. Molecular and Clinical Oncology, 22, 38. https://doi.org/10.3892/mco.2025.2833
MLA
Liang, J., Li, J., Li, B., Yang, J., Wei, Q., Li, Y."Simultaneous intravascular large B‑cell lymphoma and papillary thyroid carcinoma: A case report". Molecular and Clinical Oncology 22.5 (2025): 38.
Chicago
Liang, J., Li, J., Li, B., Yang, J., Wei, Q., Li, Y."Simultaneous intravascular large B‑cell lymphoma and papillary thyroid carcinoma: A case report". Molecular and Clinical Oncology 22, no. 5 (2025): 38. https://doi.org/10.3892/mco.2025.2833