Breast cancer metastasis to the reproductive system: Report of 2 cases and literature review: A case report

Liao,Hailing; Hou,Xiaorong; Chang,Xiaoyan

doi:10.3892/mco.2025.2839

Breast cancer metastasis to the reproductive system: Report of 2 cases and literature review: A case report

Authors:
- Hailing Liao
- Xiaorong Hou
- Xiaoyan Chang
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Affiliations: Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
Published online on: March 21, 2025 https://doi.org/10.3892/mco.2025.2839
Article Number: 44
Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metastatic involvement of the reproductive system in patients with breast cancer is rare and has been reported only a few times in the literature. Notably, among patients without clinical symptoms, reproductive system metastases are easily overlooked and difficult to distinguish from primary tumors of the reproductive system, especially when the patient is receiving endocrine therapy. The prognosis of breast cancer is better than that of other aggressive cancers. However, if distant metastasis occurs, survival decreases greatly. In the present study, 2 cases of reproductive system metastasis from breast cancer were reported and the relevant literature was reviewed to provide support for the accurate diagnosis and appropriate treatment of affected patients. Metastatic involvement of the reproductive system in patients with breast cancer is rare and has been reported only a few times in the literature. Notably, among patients without clinical symptoms, reproductive system metastases are easily overlooked and difficult to distinguish from primary tumors of the reproductive system, especially when the patient is receiving endocrine therapy. The prognosis of breast cancer is better than that of other aggressive cancers. However, if distant metastasis occurs, survival decreases greatly. In the present study, 2 cases of reproductive system metastasis from breast cancer were reported and the relevant literature was reviewed to provide support for the accurate diagnosis and appropriate treatment of affected patients.

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