Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)
- Authors:
- Stella Baliou
- Maria Adamaki
- Petros Ioannou
- Aglaia Pappa
- Mihalis I. Panayiotidis
- Ioannis Christodoulou
- Demetrios A. Spandidos
- Anthony M. Kyriakopoulos
- Vassilis Zoumpourlis
-
Affiliations: Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece, Department of Internal Medicine and Infectious Diseases, University Hospital of Heraklion, 71110 Heraklion, Greece, Department of Molecular Biology and Genetics, Faculty of Health Sciences, Democritus University of Thrace, 68100 Alexandroupolis, Greece, Department of Cancer Genetics, Therapeutics and Ultrastructural Pathology, The Cyprus Institute of Neurology and Genetics, 2371 Nicosia, Cyprus, Laboratory of Clinical Virology, Medical School, University of Crete, 71409 Heraklion, Greece, Nasco AD Biotechnology Laboratory, 18536 Piraeus, Greece - Published online on: May 31, 2021 https://doi.org/10.3892/mi.2021.3
- Article Number: 3
-
Copyright : © Baliou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
This article is mentioned in:
Abstract
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 37 (Suppl 1):S81–S90. 2014.PubMed/NCBI View Article : Google Scholar | |
Atkinson MA, Eisenbarth GS and Michels AW: Type 1 diabetes. Lancet. 383:69–82. 2014.PubMed/NCBI View Article : Google Scholar | |
Henning RJ: Type-2 diabetes mellitus and cardiovascular disease. Future Cardiol. 14:491–509. 2018.PubMed/NCBI View Article : Google Scholar | |
Chaudhury A, Duvoor C, Reddy Dendi VS, Kraleti S, Chada A, Ravilla R, Marco A, Shekhawat NS, Montales MT, Kuriakose K, et al: Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management. Front Endocrinol (Lausanne). 8(6)2017.PubMed/NCBI View Article : Google Scholar | |
Lamb RE and Goldstein BJ: Modulating an oxidative-inflammatory cascade: Potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function. Int J Clin Pract. 62:1087–1095. 2008.PubMed/NCBI View Article : Google Scholar | |
Victor VM, Rocha M, Herance R and Hernandez-Mijares A: Oxidative stress and mitochondrial dysfunction in type 2 diabetes. Curr Pharm Des. 17:3947–3958. 2011.PubMed/NCBI View Article : Google Scholar | |
Brownlee M: The pathobiology of diabetic complications: A unifying mechanism. Diabetes. 54:1615–1625. 2005.PubMed/NCBI View Article : Google Scholar | |
Asmat U, Abad K and Ismail K: Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J. 24:547–553. 2016.PubMed/NCBI View Article : Google Scholar | |
Mastrocola R, Restivo F, Vercellinatto I, Danni O, Brignardello E, Aragno M and Boccuzzi G: Oxidative and nitrosative stress in brain mitochondria of diabetic rats. J Endocrinol. 187:37–44. 2005.PubMed/NCBI View Article : Google Scholar | |
Robertson RP: Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem. 279:42351–42354. 2004.PubMed/NCBI View Article : Google Scholar | |
Ito T, Yoshikawa N, Ito H and Schaffer SW: Impact of taurine depletion on glucose control and insulin secretion in mice. J Pharmacol Sci. 129:59–64. 2015.PubMed/NCBI View Article : Google Scholar | |
Dokshina GA, Silaeva TIu and Lartsev EI: Insulin-like effects of taurine. Vopr Med Khim. 22:503–507. 1976.PubMed/NCBI(In Russian). | |
Elizarova EP and Nedosugova LV: First Experiments in Taurine Administration for Diabetes Mellitus. In: Taurine 2. Huxtable RJ, Azuma J, Kuriyama K, Nakagawa M and Baba A (eds). Springer, Boston, MA, pp583-588, 1996. | |
Damasceno DC, Netto AO, Iessi IL, Gallego FQ, Corvino SB, Dallaqua B, Sinzato YK, Bueno A, Calderon IM and Rudge MV: Streptozotocin-induced diabetes models: Pathophysiological mechanisms and fetal outcomes. BioMed Res Int. 2014(819065)2014.PubMed/NCBI View Article : Google Scholar | |
Lenzen S: The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 51:216–226. 2008.PubMed/NCBI View Article : Google Scholar | |
Szkudelski T: The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 50:537–546. 2001.PubMed/NCBI | |
Sandler S and Swenne I: Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro. Diabetologia. 25:444–447. 1983.PubMed/NCBI View Article : Google Scholar | |
El-Batch M, Hassan AM and Mahmoud HA: Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. J Agric Food Chem. 59:4995–5000. 2011.PubMed/NCBI View Article : Google Scholar | |
Hansen SH: The role of taurine in diabetes and the development of diabetic complications. Diabetes Metab Res Rev. 17:330–346. 2001.PubMed/NCBI View Article : Google Scholar | |
Das J, Vasan V and Sil PC: Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis. Toxicol Appl Pharmacol. 258:296–308. 2012.PubMed/NCBI View Article : Google Scholar | |
Gavrovskaya LK, Ryzhova OV, Safonova AF, Matveev AK and Sapronov NS: Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus. Bull Exp Biol Med. 146:226–228. 2008.PubMed/NCBI View Article : Google Scholar | |
Winiarska K, Szymanski K, Gorniak P, Dudziak M and Bryla J: Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits. Biochimie. 91:261–270. 2009.PubMed/NCBI View Article : Google Scholar | |
Budhram R, Pandya KG and Lau-Cam CA: Protection by Taurine and Thiotaurine Against Biochemical and Cellular Alterations Induced by Diabetes in a Rat Model. In: Taurine 8. El Idrissi A and L'Amoreaux WJ (eds). Springer, New York, NY, pp321-343, 2013. | |
Pandya KG, Budhram R, Clark G and Lau-Cam CA: Comparative Evaluation of Taurine and Thiotaurine as Protectants Against Diabetes-Induced Nephropathy in a Rat Model. In: Taurine 8. El Idrissi A and L'Amoreaux WJ (eds). Springer, New York, NY, pp371-394, 2013. | |
Alvarado-Vásquez N, Zamudio P, Cerón E, Vanda B, Zenteno E and Carvajal-Sandoval G: Effect of glycine in streptozotocin-induced diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol. 134:521–527. 2003.PubMed/NCBI View Article : Google Scholar | |
Goodman HO and Shihabi ZK: Supplemental taurine in diabetic rats: Effects on plasma glucose and triglycerides. Biochem Med Metab Biol. 43:1–9. 1990.PubMed/NCBI View Article : Google Scholar | |
Di Leo MAS, Santini SA, Silveri NG, Giardina B, Franconi F and Ghirlanda G: Long-term taurine supplementation reduces mortality rate in streptozotocin-induced diabetic rats. Amino Acids. 27:187–191. 2004.PubMed/NCBI View Article : Google Scholar | |
Abebe W: Effects of taurine on the reactivity of aortas from diabetic rats. Life Sci. 82:279–289. 2008.PubMed/NCBI View Article : Google Scholar | |
Ulrich-Merzenich G, Zeitler H, Vetter H and Bhonde RR: Protective effects of taurine on endothelial cells impaired by high glucose and oxidized low density lipoproteins. Eur J Nutr. 46:431–438. 2007.PubMed/NCBI View Article : Google Scholar | |
Wang CF, Yuan JR, Qin D, Gu JF, Zhao BJ, Zhang L, Zhao D, Chen J, Hou XF, Yang N, et al: Protection of tauroursodeoxycholic acid on high glucose-induced human retinal microvascular endothelial cells dysfunction and streptozotocin-induced diabetic retinopathy rats. J Ethnopharmacol. 185:162–170. 2016.PubMed/NCBI View Article : Google Scholar | |
Ogasawara M, Nakamura T, Koyama I, Nemoto M and Yoshida T: Reactivity of taurine with aldehydes and its physiological role. Chem Pharm Bull (Tokyo). 41:2172–2175. 1993.PubMed/NCBI View Article : Google Scholar | |
Casey RG, Gang C, Joyce M and Bouchier-Hayes DJ: Taurine attenuates acute hyperglycaemia-induced endothelial cell apoptosis, leucocyte-endothelial cell interactions and cardiac dysfunction. J Vasc Res. 44:31–39. 2007.PubMed/NCBI View Article : Google Scholar | |
Wang LJ, Yu YH, Zhang LG, Wang Y, Niu N, Li Q and Guo LM: Taurine rescues vascular endothelial dysfunction in streptozocin-induced diabetic rats: Correlated with downregulation of LOX-1 and ICAM-1 expression on aortas. Eur J Pharmacol. 597:75–80. 2008.PubMed/NCBI View Article : Google Scholar | |
Mochizuki H, Takido J and Yokogoshi H: Effect of dietary taurine on endogenous hypercholesterolemia in rats fed on phenobarbital-containing diets. Biosci Biotechnol Biochem. 63:1298–1300. 1999.PubMed/NCBI View Article : Google Scholar | |
Mohamed NA and Gawad HSA: Taurine dietary supplementation attenuates brain, thyroid, testicular disturbances and oxidative stress in streptozotocin-induced diabetes mellitus in male rats. Beni Suef Univ J Basic Appl Sci. 6:247–252. 2017. | |
Lieber CS: Cytochrome P-4502E1: Its physiological and pathological role. Physiol Rev. 77:517–544. 1997.PubMed/NCBI View Article : Google Scholar | |
Fukuda N, Yoshitama A, Sugita S, Fujita M and Murakami S: Dietary taurine reduces hepatic secretion of cholesteryl ester and enhances fatty acid oxidation in rats fed a high-cholesterol diet. J Nutr Sci Vitaminol (Tokyo). 57:144–149. 2011.PubMed/NCBI View Article : Google Scholar | |
Rashid K, Das J and Sil PC: Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats. Food Chem Toxicol. 51:317–329. 2013.PubMed/NCBI View Article : Google Scholar | |
Patel SN and Lau-Cam CA: The Effect of Taurine and Its Immediate Homologs on Diabetes-Induced Oxidative Stress in the Brain and Spinal Cord of Rats. In: Taurine 10. Lee DH, Schaffer SW, Park E and Kim HW (eds). Springer, Dordrecht, pp337-351, 2017. | |
Acharya M and Lau-Cam CA: Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. J Biomed Sci. 17 (Suppl 1)(S35)2010.PubMed/NCBI View Article : Google Scholar | |
Furfaro AL, Nitti M, Marengo B, Domenicotti C, Cottalasso D, Marinari UM, Pronzato MA and Traverso N: Impaired synthesis contributes to diabetes-induced decrease in liver glutathione. Int J Mol Med. 29:899–905. 2012.PubMed/NCBI View Article : Google Scholar | |
Aydın AF, Çoban J, Doğan-Ekici I, Betül-Kalaz E, Doğru-Abbasoğlu S and Uysal M: Carnosine and taurine treatments diminished brain oxidative stress and apoptosis in D-galactose aging model. Metab Brain Dis. 31:337–345. 2016.PubMed/NCBI View Article : Google Scholar | |
Arany E, Strutt B, Romanus P, Remacle C, Reusens B and Hill DJ: Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice. Diabetologia. 47:1831–1837. 2004.PubMed/NCBI View Article : Google Scholar | |
Pandya KG, Budhram R, Clark G and Lau-Cam CA: Comparative evaluation of taurine and thiotaurine as protectants against diabetes-induced nephropathy in a rat model. Adv Exp Med Biol. 775:371–394. 2013.PubMed/NCBI View Article : Google Scholar | |
Batista TM, Ribeiro RA, Amaral AG, de Oliveira CAM, Boschero AC and Carneiro EM: Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats: Involvement of Ach-M3R, Synt 1 and SNAP-25 proteins. J Nutr Biochem. 23:306–312. 2012.PubMed/NCBI View Article : Google Scholar | |
Vettorazzi JF, Ribeiro RA, Santos-Silva JC, Borck PC, Batista TM, Nardelli TR, Boschero AC and Carneiro EM: Taurine supplementation increases K(ATP) channel protein content, improving Ca2+ handling and insulin secretion in islets from malnourished mice fed on a high-fat diet. Amino Acids. 46:2123–2136. 2014.PubMed/NCBI View Article : Google Scholar | |
Lin S, Wu G, Zhao D, Han J, Yang Q, Feng Y, Liu M, Yang J and Hu J: Taurine increases insulin expression in STZ-treated rat islet cells in vitro. Adv Exp Med Biol. 975:319–328. 2017.PubMed/NCBI View Article : Google Scholar | |
Carneiro EM, Latorraca MQ, Araujo E, Beltrá M, Oliveras MJ, Navarro M, Berná G, Bedoya FJ, Velloso LA and Soria B: Taurine supplementation modulates glucose homeostasis and islet function. J Nutr Biochem. 20:503–511. 2009.PubMed/NCBI View Article : Google Scholar | |
Santos-Silva JC, Ribeiro RA, Vettorazzi JF, Irles E, Rickli S, Borck PC, Porciuncula PM, Quesada I, Nadal A, Boschero AC, et al: Taurine supplementation ameliorates glucose homeostasis, prevents insulin and glucagon hypersecretion, and controls β, α, and δ-cell masses in genetic obese mice. Amino Acids. 47:1533–1548. 2015.PubMed/NCBI View Article : Google Scholar | |
Kataoka K: Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes. J Biochem. 141:775–781. 2007.PubMed/NCBI View Article : Google Scholar | |
Kim JY, Chu K, Kim HJ, Seong HA, Park KC, Sanyal S, Takeda J, Ha H, Shong M, Tsai MJ, et al: Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. Mol Endocrinol. 18:776–790. 2004.PubMed/NCBI View Article : Google Scholar | |
Yildirim Z and Kilic N: Effects of Taurine and Age on Cerebellum Antioxidant Status and Oxidative Stress. Int J Gerontol. 5:166–170. 2011. | |
Raza H, John A and Howarth FC: Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain. Cell Physiol Biochem. 35:1241–1251. 2015.PubMed/NCBI View Article : Google Scholar | |
El Idrissi A and L'Amoreaux WJ: Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: In vivo functional test for the activity of glutamic acid decarboxylase. Neuroscience. 156:693–699. 2008.PubMed/NCBI View Article : Google Scholar | |
L'Amoreaux WJ, Marsillo A and El Idrissi A: Pharmacological characterization of GABAA receptors in taurine-fed mice. J Biomed Sci. 17 (Suppl 1)(S14)2010.PubMed/NCBI View Article : Google Scholar | |
Caletti G, Almeida FB, Agnes G, Nin MS, Barros HMT and Gomez R: Antidepressant dose of taurine increases mRNA expression of GABAA receptor α2 subunit and BDNF in the hippocampus of diabetic rats. Behav Brain Res. 283:11–15. 2015.PubMed/NCBI View Article : Google Scholar | |
Li F, Obrosova IG, Abatan O, Tian D, Larkin D, Stuenkel EL and Stevens MJ: Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats. Am J Physiol Endocrinol Metab. 288:E29–E36. 2005.PubMed/NCBI View Article : Google Scholar | |
Li F, Abatan OI, Kim H, Burnett D, Larkin D, Obrosova IG and Stevens MJ: Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats. Neurobiol Dis. 22:669–676. 2006.PubMed/NCBI View Article : Google Scholar | |
Das J, Roy A and Sil PC: Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: A review. Food Funct. 3:1251–1264. 2012.PubMed/NCBI View Article : Google Scholar | |
Chen WQ, Jin H, Nguyen M, Carr J, Lee YJ, Hsu CC, Faiman MD, Schloss JV and Wu JY: Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons. J Neurosci Res. 66:612–619. 2001.PubMed/NCBI View Article : Google Scholar | |
Agca CA, Tuzcu M, Hayirli A and Sahin K: Taurine ameliorates neuropathy via regulating NF-κB and Nrf2/HO-1 signaling cascades in diabetic rats. Food Chem Toxicol. 71:116–121. 2014.PubMed/NCBI View Article : Google Scholar | |
Abd El-Twab SM, Mohamed HM and Mahmoud AM: Taurine and pioglitazone attenuate diabetes-induced testicular damage by abrogation of oxidative stress and up-regulation of the pituitary-gonadal axis. Can J Physiol Pharmacol. 94:651–661. 2016.PubMed/NCBI View Article : Google Scholar | |
Buettner R, Schölmerich J and Bollheimer LC: High-fat diets: Modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring). 15:798–808. 2007.PubMed/NCBI View Article : Google Scholar | |
Schrauwen P and Hesselink MKC: Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes. 53:1412–1417. 2004.PubMed/NCBI View Article : Google Scholar | |
Iossa S, Mollica MP, Lionetti L, Crescenzo R, Botta M and Liverini G: Skeletal muscle oxidative capacity in rats fed high-fat diet. Int J Obes. 26:65–72. 2002.PubMed/NCBI View Article : Google Scholar | |
Rani AJ and Mythili SV: Study on total antioxidant status in relation to oxidative stress in type 2 diabetes mellitus. J Clin Diagn Res. 8:108–110. 2014.PubMed/NCBI View Article : Google Scholar | |
Franconi F, Bennardini F, Mattana A, Miceli M, Ciuti M, Mian M, Gironi A, Anichini R and Seghieri G: Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: Effects of taurine supplementation. Am J Clin Nutr. 61:1115–1119. 1995.PubMed/NCBI View Article : Google Scholar | |
Yamori Y, Liu L, Mori M, Sagara M, Murakami S, Nara Y and Mizushima S: Taurine as the Nutritional Factor for the Longevity of the Japanese Revealed by a World-Wide Epidemiological Survey. Adv Exp Med Biol. 643:13–25. 2009.PubMed/NCBI View Article : Google Scholar | |
Merheb M, Daher RT, Nasrallah M, Sabra R, Ziyadeh FN and Barada K: Taurine intestinal absorption and renal excretion test in diabetic patients: A pilot study. Diabetes Care. 30:2652–2654. 2007.PubMed/NCBI View Article : Google Scholar | |
Kim KS, Oh DH, Kim JY, Lee BG, You JS, Chang KJ, Chung HJ, Yoo MC, Yang HI, Kang JH, et al: Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes. Exp Mol Med. 44:665–673. 2012.PubMed/NCBI View Article : Google Scholar | |
Harada H, Tsujino T, Watari Y, Nonaka H, Emoto N and Yokoyama M: Oral taurine supplementation prevents fructose-induced hypertension in rats. Heart Vessels. 19:132–136. 2004.PubMed/NCBI View Article : Google Scholar | |
Chauncey KB, Tenner TE Jr, Lombardini JB, Jones BG, Brooks ML, Warner RD, Davis RL and Ragain RM: The effect of taurine supplementation on patients with type 2 diabetes mellitus. Adv Exp Med Biol. 526:91–96. 2003.PubMed/NCBI View Article : Google Scholar | |
Xiao C, Giacca A and Lewis GF: Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia. 51:139–146. 2008.PubMed/NCBI View Article : Google Scholar | |
Nakaya Y, Minami A, Harada N, Sakamoto S, Niwa Y and Ohnaka M: Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes. Am J Clin Nutr. 71:54–58. 2000.PubMed/NCBI View Article : Google Scholar | |
Parvez S, Tabassum H, Banerjee BD and Raisuddin S: Taurine prevents tamoxifen-induced mitochondrial oxidative damage in mice. Basic Clin Pharmacol Toxicol. 102:382–387. 2008.PubMed/NCBI View Article : Google Scholar | |
Liu Y and Quinn MR: Chemokine production by rat alveolar macrophages is inhibited by taurine chloramine. Immunol Lett. 80:27–32. 2002.PubMed/NCBI View Article : Google Scholar | |
Barua M, Liu Y and Quinn MR: Taurine chloramine inhibits inducible nitric oxide synthase and TNF-alpha gene expression in activated alveolar macrophages: decreased NF-kappaB activation and IkappaB kinase activity. J Immunol. 167:2275–2281. 2001.PubMed/NCBI View Article : Google Scholar | |
Camargo RL, Batista TM, Ribeiro RA, Velloso LA, Boschero AC and Carneiro EM: Effects of Taurine Supplementation Upon Food Intake and Central Insulin Signaling in Malnourished Mice Fed on a High-Fat Diet. In: Taurine 8. El Idrissi A and L'Amoreaux WJ (eds). Springer, New York, NY, pp93-103, 2013. | |
El Idrissi A and Trenkner E: Growth factors and taurine protect against excitotoxicity by stabilizing calcium homeostasis and energy metabolism. J Neurosci. 19:9459–9468. 1999.PubMed/NCBI View Article : Google Scholar | |
Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, et al: Free fatty acid-induced reduction in glucose-stimulated insulin secretion: Evidence for a role of oxidative stress in vitro and in vivo. Diabetes. 56:2927–2937. 2007.PubMed/NCBI View Article : Google Scholar | |
Jong CJ, Azuma J and Schaffer S: Mechanism underlying the antioxidant activity of taurine: Prevention of mitochondrial oxidant production. Amino Acids. 42:2223–2232. 2012.PubMed/NCBI View Article : Google Scholar | |
Suzuki T, Suzuki T, Wada T, Saigo K and Watanabe K: Taurine as a constituent of mitochondrial tRNAs: New insights into the functions of taurine and human mitochondrial diseases. EMBO J. 21:6581–6589. 2002.PubMed/NCBI View Article : Google Scholar | |
Kirino Y, Yasukawa T, Ohta S, Akira S, Ishihara K, Watanabe K and Suzuki T: Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci USA. 101:15070–15075. 2004.PubMed/NCBI View Article : Google Scholar | |
Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST and Lowell BB: Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction. J Clin Invest. 112:1831–1842. 2003.PubMed/NCBI View Article : Google Scholar | |
Kondo Y, Toda Y, Kitajima H, Oda H, Nagate T, Kameo K and Murakami S: Taurine inhibits development of atherosclerotic lesions in apolipoprotein E-deficient mice. Clin Exp Pharmacol Physiol. 28:809–815. 2001.PubMed/NCBI View Article : Google Scholar | |
Murakami S, Kondo Y, Sakurai T, Kitajima H and Nagate T: Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits. Atherosclerosis. 163:79–87. 2002.PubMed/NCBI View Article : Google Scholar | |
Cappelli AP, Zoppi CC, Barbosa-Sampaio HC, Costa JM Jr, Protzek AO, Morato PN, Boschero AC and Carneiro EM: Taurine-induced insulin signalling improvement of obese malnourished mice is associated with redox balance and protein phosphatases activity modulation. Liver Int. 34:771–783. 2014.PubMed/NCBI View Article : Google Scholar | |
Haber CA, Lam TKT, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A and Fantus IG: N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: Possible role of oxidative stress. Am J Physiol Endocrinol Metab. 285:E744–E753. 2003.PubMed/NCBI View Article : Google Scholar | |
González-Chávez A, Elizondo-Argueta S, Gutiérrez-Reyes G and León-Pedroza JI: Pathophysiological implications between chronic inflammation and the development of diabetes and obesity. Cir Cir. 79:209–216. 2011.PubMed/NCBI | |
You JS, Zhao X, Kim SH and Chang KJ: Positive Correlation Between Serum Taurine and Adiponectin Levels in High-Fat Diet-Induced Obesity Rats. In: Taurine 8. El Idrissi A and L'Amoreaux WJ (eds). Springer, New York, NY, pp105-111, 2013. | |
Wu N, Lu Y, He B, Zhang Y, Lin J, Zhao S, Zhang W, Li Y and Han P: Taurine prevents free fatty acid-induced hepatic insulin resistance in association with inhibiting JNK1 activation and improving insulin signaling in vivo. Diabetes Res Clin Pract. 90:288–296. 2010.PubMed/NCBI View Article : Google Scholar | |
Rosa FT, Freitas EC, Deminice R, Jordão AA and Marchini JS: Oxidative stress and inflammation in obesity after taurine supplementation: A double-blind, placebo-controlled study. Eur J Nutr. 53:823–830. 2014.PubMed/NCBI View Article : Google Scholar | |
Lim JG, Lee HY, Yun JE, Kim SP, Park JW, Suh SI, Jang BC, Cho CH, Bae JH, Kim SS, et al: Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes. Biochem Pharmacol. 68:901–910. 2004.PubMed/NCBI View Article : Google Scholar | |
Park EJ, Bae JH, Kim SY, Lim JG, Baek WK, Kwon TK, Suh SI, Park JW, Lee IK, Ashcroft FM, et al: Inhibition of ATP-sensitive K+ channels by taurine through a benzamido-binding site on sulfonylurea receptor 1. Biochem Pharmacol. 67:1089–1096. 2004.PubMed/NCBI View Article : Google Scholar | |
Koh JH, Lee ES, Hyun M, Kim HM, Choi YJ, Lee EY, Yadav D and Chung CH: Taurine alleviates the progression of diabetic nephropathy in type 2 diabetic rat model. Int J Endocrinol. 2014(397307)2014.PubMed/NCBI View Article : Google Scholar | |
Thadani JM, Marathe A, Vakodikar S, Kshatriya P, Modi D and Vyas R: Treatment of Type I Diabetes using Autologous Adipose Derived Mesenchymal Stem Cells Translated to Insulin Secreting Islet like Cell Aggregates. J Case Rep. 7:235–238. 2017. | |
Fujihira E, Takahashi H and Nakazawa M: Effect of long-term feeding of taurine in hereditary hyperglycemic obese mice. Chem Pharm Bull (Tokyo). 18:1636–1642. 1970.PubMed/NCBI View Article : Google Scholar | |
Tsuboyama-Kasaoka N, Shozawa C, Sano K, Kamei Y, Kasaoka S, Hosokawa Y and Ezaki O: Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Endocrinology. 147:3276–3284. 2006.PubMed/NCBI View Article : Google Scholar | |
Piña-Zentella G, de la Rosa-Cuevas G, Vázquez-Meza H, Piña E and de Piña MZ: Taurine in adipocytes prevents insulin-mediated H2O2 generation and activates Pka and lipolysis. Amino Acids. 42:1927–1935. 2012.PubMed/NCBI View Article : Google Scholar | |
Nardelli TR, Ribeiro RA, Balbo SL, Vanzela EC, Carneiro EM, Boschero AC and Bonfleur ML: Taurine prevents fat deposition and ameliorates plasma lipid profile in monosodium glutamate-obese rats. Amino Acids. 41:901–908. 2011.PubMed/NCBI View Article : Google Scholar | |
Cao PJ, Jin YJ, Li ME, Zhou R and Yang MZ: PGC-1α may associated with the anti-obesity effect of taurine on rats induced by arcuate nucleus lesion. Nutr Neurosci. 19:86–93. 2016.PubMed/NCBI View Article : Google Scholar | |
Batista TM, Ribeiro RA, da Silva PMR, Camargo RL, Lollo PCB, Boschero AC and Carneiro EM: Taurine supplementation improves liver glucose control in normal protein and malnourished mice fed a high-fat diet. Mol Nutr Food Res. 57:423–434. 2013.PubMed/NCBI View Article : Google Scholar | |
Kim KS, Choi HM, Ji HI, Kim C, Kim JY, Song R, Kim SM, Lee YA, Lee SH, Yang HI, et al: Effect of taurine chloramine on differentiation of human preadipocytes into adipocytes. Adv Exp Med Biol. 775:247–257. 2013.PubMed/NCBI View Article : Google Scholar | |
Kim KS, Ji HI, Chung H, Kim C, Lee SH, Lee YA, Yang HI, Yoo MC and Hong SJ: Taurine chloramine modulates the expression of adipokines through inhibition of the STAT-3 signaling pathway in differentiated human adipocytes. Amino Acids. 45:1415–1422. 2013.PubMed/NCBI View Article : Google Scholar | |
Kim KS, You JS, Kim JY, Chang KJ, Yoo MC, Song R, Lee YA, Lee SH, Hong SJ and Yang HI: Taurine ameliorates hypercholesterolemia but not obesity in rats fed a lard-based, high-fat diet. Adv Exp Med Biol. 803:271–278. 2015.PubMed/NCBI View Article : Google Scholar | |
Murakami S, Nara Y and Yamori Y: Taurine accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats. Life Sci. 58:1643–1651. 1996.PubMed/NCBI View Article : Google Scholar | |
Chen W, Matuda K, Nishimura N and Yokogoshi H: The effect of taurine on cholesterol degradation in mice fed a high-cholesterol diet. Life Sci. 74:1889–1898. 2004.PubMed/NCBI View Article : Google Scholar | |
Choi MJ, Kim JH and Chang KJ: The effect of dietary taurine supplementation on plasma and liver lipid concentrations and free amino acid concentrations in rats fed a high-cholesterol diet. Adv Exp Med Biol. 583:235–242. 2006.PubMed/NCBI View Article : Google Scholar | |
Kishida T, Miyazato S, Ogawa H and Ebihara K: Taurine prevents hypercholesterolemia in ovariectomized rats fed corn oil but not in those fed coconut oil. J Nutr. 133:2616–2621. 2003.PubMed/NCBI View Article : Google Scholar | |
Nishimura N, Yamamoto T and Ota T: Taurine feeding inhibits bile acid absorption from the ileum in rats fed a high cholesterol and high fat diet. Adv Exp Med Biol. 643:285–291. 2009.PubMed/NCBI View Article : Google Scholar | |
Murakami S, Kondo Y, Toda Y, Kitajima H, Kameo K, Sakono M and Fukuda N: Effect of taurine on cholesterol metabolism in hamsters: Up-regulation of low density lipoprotein (LDL) receptor by taurine. Life Sci. 70:2355–2366. 2002.PubMed/NCBI View Article : Google Scholar | |
Yanagita T, Han SY, Hu Y, Nagao K, Kitajima H and Murakami S: Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells. Lipids Health Dis. 7(38)2008.PubMed/NCBI View Article : Google Scholar | |
Ahmadian M, Roshan VD, Aslani E and Stannard SR: Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure. Ther Adv Cardiovasc Dis. 11:185–194. 2017.PubMed/NCBI View Article : Google Scholar | |
Nandhini AT and Anuradha CV: Taurine modulates kallikrein activity and glucose metabolism in insulin resistant rats. Amino Acids. 22:27–38. 2002.PubMed/NCBI View Article : Google Scholar | |
Mikami N, Hosokawa M and Miyashita K: Dietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic/obese KK-A(y) mice. J Food Sci. 77:H114–H120. 2012.PubMed/NCBI View Article : Google Scholar | |
Harada N, Ninomiya C, Osako Y, Morishima M, Mawatari K, Takahashi A and Nakaya Y: Taurine alters respiratory gas exchange and nutrient metabolism in type 2 diabetic rats. Obes Res. 12:1077–1084. 2004.PubMed/NCBI View Article : Google Scholar | |
Solon CS, Franci D, Ignacio-Souza LM, Romanatto T, Roman EA, Arruda AP, Morari J, Torsoni AS, Carneiro EM and Velloso LA: Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats. Amino Acids. 42:2403–2410. 2012.PubMed/NCBI View Article : Google Scholar | |
Figueroa ALC, Figueiredo H, Rebuffat SA, Vieira E and Gomis R: Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet. Sci Rep. 6(36801)2016.PubMed/NCBI View Article : Google Scholar | |
Ribeiro RA, Santos-Silva JC, Vettorazzi JF, Cotrim BB, Mobiolli DDM, Boschero AC and Carneiro EM: Taurine supplementation prevents morpho-physiological alterations in high-fat diet mice pancreatic β-cells. Amino Acids. 43:1791–1801. 2012.PubMed/NCBI View Article : Google Scholar | |
McCarthy FP, Delany AC, Kenny LC and Walsh SK: PPAR-γ - a possible drug target for complicated pregnancies. Br J Pharmacol. 168:1074–1085. 2013.PubMed/NCBI View Article : Google Scholar | |
Fujita T and Sato Y: Changes in blood pressure and extracellular fluid with taurine in DOCA-salt rats. Am J Physiol. 250:R1014–R1020. 1986.PubMed/NCBI View Article : Google Scholar | |
Branco RC, Batista TM, Camargo RL, Borck PC, Ribeiro RA, Zoppi CC, Lollo PC, Morato PN, Boschero AC and Carneiro EM: Long-term taurine supplementation leads to enhanced hepatic steatosis, renal dysfunction and hyperglycemia in mice fed on a high-fat diet. Adv Exp Med Biol. 803:339–351. 2015.PubMed/NCBI View Article : Google Scholar | |
Ware LB, Johnson ACM and Zager RA: Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury. Am J Physiol Renal Physiol. 300:F628–F638. 2011.PubMed/NCBI View Article : Google Scholar | |
Declèves AE, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP, Nortier JL, Farquhar MG, Naviaux RK, et al: Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury. Kidney Int. 85:611–623. 2014.PubMed/NCBI View Article : Google Scholar | |
Wang L, Zhang L, Yu Y, Wang Y and Niu N: The protective effects of taurine against early renal injury in STZ-induced diabetic rats, correlated with inhibition of renal LOX-1-mediated ICAM-1 expression. Ren Fail. 30:763–771. 2008.PubMed/NCBI View Article : Google Scholar | |
He X, Duan Y, Yao K, Li F, Hou Y, Wu G and Yin Y: β-Hydroxy-β-methylbutyrate, mitochondrial biogenesis, and skeletal muscle health. Amino Acids. 48:653–664. 2016.PubMed/NCBI View Article : Google Scholar | |
Tran LT, Yuen VG and McNeill JH: The fructose-fed rat: A review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol Cell Biochem. 332:145–159. 2009.PubMed/NCBI View Article : Google Scholar | |
Bantle JP, Raatz SK, Thomas W and Georgopoulos A: Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr. 72:1128–1134. 2000.PubMed/NCBI View Article : Google Scholar | |
Nandhini ATA, Thirunavukkarasu V and Anuradha CV: Potential role of kinins in the effects of taurine in high-fructose-fed rats. Can J Physiol Pharmacol. 82:1–8. 2004.PubMed/NCBI View Article : Google Scholar | |
Rahman MM, Park HM, Kim SJ, Go HK, Kim GB, Hong CU, Lee YU, Kim SZ, Kim JS and Kang HS: Taurine prevents hypertension and increases exercise capacity in rats with fructose-induced hypertension. Am J Hypertens. 24:574–581. 2011.PubMed/NCBI View Article : Google Scholar | |
Larsen LH, Orstrup LKH, Hansen SH, Grunnet N, Quistorff B and Mortensen OH: The effect of long-term taurine supplementation and fructose feeding on glucose and lipid homeostasis in Wistar rats. Adv Exp Med Biol. 776:39–50. 2013.PubMed/NCBI View Article : Google Scholar | |
Pilkis SJ and Granner DK: Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol. 54:885–909. 1992.PubMed/NCBI View Article : Google Scholar | |
Lau-Cam CA and Patel JP: Comparison of the effects of taurine with those of related sulfur-containing compounds on pyridoxal-induced adrenomedullary catecholamine release and glycogenolysis in the rat. Adv Exp Med Biol. 583:203–212. 2006.PubMed/NCBI View Article : Google Scholar | |
El Mesallamy HO, El-Demerdash E, Hammad LN and El Magdoub HM: Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance. Diabetol Metab Syndr. 2(46)2010.PubMed/NCBI View Article : Google Scholar | |
Devasagayam TPA, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS and Lele RD: Free radicals and antioxidants in human health: Current status and future prospects. J Assoc Physicians India. 52:794–804. 2004.PubMed/NCBI | |
Rask-Madsen C and King GL: Mechanisms of Disease: Endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab. 3:46–56. 2007.PubMed/NCBI View Article : Google Scholar | |
Moloney MA, Casey RG, O'Donnell DH, Fitzgerald P, Thompson C and Bouchier-Hayes DJ: Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res. 7:300–310. 2010.PubMed/NCBI View Article : Google Scholar | |
Ito T, Schaffer SW and Azuma J: The potential usefulness of taurine on diabetes mellitus and its complications. Amino Acids. 42:1529–1539. 2012.PubMed/NCBI View Article : Google Scholar | |
Fennessy FM, Moneley DS, Wang JH, Kelly CJ and Bouchier-Hayes DJ: Taurine and vitamin C modify monocyte and endothelial dysfunction in young smokers. Circulation. 107:410–415. 2003.PubMed/NCBI View Article : Google Scholar | |
Zhang M, Bi LF, Fang JH, Su XL, Da GL, Kuwamori T and Kagamimori S: Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids. 26:267–271. 2004.PubMed/NCBI View Article : Google Scholar | |
Mizushima S, Nara Y, Sawamura M and Yamori Y: Effects of Oral Taurine Supplementation on Lipids and Sympathetic Nerve Tone. In: Taurine 2. Huxtable RJ, Azuma J, Kuriyama K, Nakagawa M and Baba A (eds). Springer, Boston, MA, pp615-622, 1996. | |
Nakamura T, Ushiyama C, Suzuki S, Shimada N, Ohmuro H, Ebihara I and Koide H: Effects of taurine and vitamin E on microalbuminuria, plasma metalloproteinase-9, and serum type IV collagen concentrations in patients with diabetic nephropathy. Nephron J. 83:361–362. 1999.PubMed/NCBI View Article : Google Scholar | |
Cusworth DC and Dent CE: Renal clearances of amino acids in normal adults and in patients with aminoaciduria. Biochem J. 74:550–561. 1960.PubMed/NCBI View Article : Google Scholar | |
Mozaffari MS and Schaffer D: Taurine modulates arginine vasopressin-mediated regulation of renal function. J Cardiovasc Pharmacol. 37:742–750. 2001.PubMed/NCBI View Article : Google Scholar | |
Burg MB: Molecular basis of osmotic regulation. Am J Physiol. 268:F983–F996. 1995.PubMed/NCBI View Article : Google Scholar | |
Gomez RA, Tufro-McReddie A, Everett AD and Pentz ES: Ontogeny of renin and AT1 receptor in the rat. Pediatr Nephrol. 7:635–638. 1993.PubMed/NCBI View Article : Google Scholar | |
Han X and Chesney RW: The role of taurine in renal disorders. Amino Acids. 43:2249–2263. 2012.PubMed/NCBI View Article : Google Scholar | |
Hagar HH, El Etter E and Arafa M: Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats. Clin Exp Pharmacol Physiol. 33:189–196. 2006.PubMed/NCBI View Article : Google Scholar | |
Ideishi M, Miura S, Sakai T, Sasaguri M, Misumi Y and Arakawa K: Taurine amplifies renal kallikrein and prevents salt-induced hypertension in Dahl rats. J Hypertens. 12:653–661. 1994.PubMed/NCBI | |
Dawson R Jr, Biasetti M, Messina S and Dominy J: The cytoprotective role of taurine in exercise-induced muscle injury. Amino Acids. 22:309–324. 2002.PubMed/NCBI View Article : Google Scholar | |
Hu J, Xu X, Yang J, Wu G, Sun C and Lv Q: Antihypertensive Effect of Taurine in Rat. In: Taurine 7. Azuma J, Schaffer SW and Ito T (eds). Springer, New York, NY, pp75-84, 2009. | |
Mozaffari MS, Abdelsayed R, Patel C and Schaffer SW: Effects of Dietary Salt and Fat on Taurine Excretion in Healthy and Diseased Rats. In: Taurine 6. Oja SS and Saransaari P (eds). Springer, Boston, MA, pp173-180, 2006. | |
Venkatesan N, Venkatesan P, Karthikeyan J and Arumugam V: Protection by taurine against adriamycin-induced proteinuria and hyperlipidemia in rats. Proc Soc Exp Biol Med. 215:158–164. 1997.PubMed/NCBI View Article : Google Scholar | |
Chesney RW, Han X and Patters AB: Taurine and the renal system. J Biomed Sci. 17 (Suppl 1)(S4)2010.PubMed/NCBI View Article : Google Scholar | |
Koeners MP, Braam B, van der Giezen DM, Goldschmeding R and Joles JA: Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats. Am J Hypertens. 23:802–808. 2010.PubMed/NCBI View Article : Google Scholar | |
Hsueh WA and Wyne K: Renin-Angiotensin-aldosterone system in diabetes and hypertension. J Clin Hypertens (Greenwich). 13:224–237. 2011.PubMed/NCBI View Article : Google Scholar | |
Takahashi K, Azuma M, Taira K, Baba A, Yamamoto I, Schaffer SW and Azuma J: Effect of taurine on angiotensin II-induced hypertrophy of neonatal rat cardiac cells. J Cardiovasc Pharmacol. 30:725–730. 1997.PubMed/NCBI View Article : Google Scholar | |
Azuma M, Takahashi K, Fukuda T, Ohyabu Y, Yamamoto I, Kim S, Iwao H, Schaffer SW and Azuma J: Taurine attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac myocytes. Eur J Pharmacol. 403:181–188. 2000.PubMed/NCBI View Article : Google Scholar | |
Nara Y, Yamori Y and Lovenberg W: Effect of dietary taurine on blood pressure in spontaneously hypertensive rats. Biochem Pharmacol. 27:2689–2692. 1978.PubMed/NCBI View Article : Google Scholar | |
Yamamoto J, Akabane S, Yoshimi H, Nakai M and Ikeda M: Effects of taurine on stress-evoked hemodynamic and plasma catecholamine changes in spontaneously hypertensive rats. Hypertension. 7:913–922. 1985.PubMed/NCBI View Article : Google Scholar | |
Sato Y, Ogata E and Fujita T: Hypotensive action of taurine in DOCA-salt rats--involvement of sympathoadrenal inhibition and endogenous opiate. Jpn Circ J. 55:500–508. 1991.PubMed/NCBI View Article : Google Scholar | |
Patrick L: Lead toxicity part II: The role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev. 11:114–127. 2006.PubMed/NCBI | |
Roysommuti S, Suwanich A, Lerdweeraphon W, Thaeomor A, Jirakulsomchok D and Wyss JM: Sex dependent effects of perinatal taurine exposure on the arterial pressure control in adult offspring. Adv Exp Med Biol. 643:135–144. 2009.PubMed/NCBI View Article : Google Scholar | |
Malpas SC, Ramchandra R, Guild SJ, McBryde F and Barrett CJ: Renal sympathetic nerve activity in the development of hypertension. Curr Hypertens Rep. 8:242–248. 2006.PubMed/NCBI View Article : Google Scholar | |
Hano T, Kasano M, Tomari H and Iwane N: Taurine Suppresses Pressor Response Through the Inhibition of Sympathetic Nerve Activity and the Improvement in Baro-Reflex Sensitivity of Spontaneously Hypertensive Rats. In: Taurine 7. Azuma J, SchafferSW and Ito T (eds). Springer, New York, NY, pp57-63, 2009. | |
Iimura O and Shimamoto K: Salt and Hypertension: Water-Sodium Handling in Essential Hypertension. Ann N Y Acad Sci. 676:105–121. 1993.PubMed/NCBI View Article : Google Scholar | |
Sun Q, Wang B, Li Y, Sun F, Li P, Xia W, Zhou X, Li Q, Wang X, Chen J, et al: Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Hypertension. 67:541–549. 2016.PubMed/NCBI View Article : Google Scholar | |
Katakawa M, Fukuda N, Tsunemi A, Mori M, Maruyama T, Matsumoto T, Abe M and Yamori Y: Taurine and magnesium supplementation enhances the function of endothelial progenitor cells through antioxidation in healthy men and spontaneously hypertensive rats. Hypertens Res. 39:848–856. 2016.PubMed/NCBI View Article : Google Scholar | |
Abebe W and Mozaffari MS: Effects of chronic taurine treatment on reactivity of the rat aorta. Amino Acids. 19:615–623. 2000.PubMed/NCBI View Article : Google Scholar | |
Dawson R Jr, Liu S, Jung B, Messina S and Eppler B: Effects of high salt diets and taurine on the development of hypertension in the stroke-prone spontaneously hypertensive rat. Amino Acids. 19:643–665. 2000.PubMed/NCBI View Article : Google Scholar | |
Maia AR, Batista TM, Victorio JA, Clerici SP, Delbin MA, Carneiro EM and Davel AP: Taurine supplementation reduces blood pressure and prevents endothelial dysfunction and oxidative stress in post-weaning protein-restricted rats. PLoS One. 9(e105851)2014.PubMed/NCBI View Article : Google Scholar | |
Ogawa M, Takahara A, Ishijima M and Tazaki S: Decrease of plasma sulfur amino acids in essential hypertension. Jpn Circ J. 49:1217–1224. 1985.PubMed/NCBI View Article : Google Scholar | |
Yamori Y, Taguchi T, Hamada A, Kunimasa K, Mori H and Mori M: Taurine in health and diseases: Consistent evidence from experimental and epidemiological studies. J Biomed Sci. 17 (Suppl 1)(S6)2010.PubMed/NCBI View Article : Google Scholar | |
Yamori Y, Nara Y, Ikeda K and Mizushima S: Is Taurine a Preventive Nutritional Factor of Cardiovascular Diseases or Just a Biological Marker of Nutrition. In: Taurine 2. Huxtable RJ, Azuma J, Kuriyama K, Nakagawa M and Baba A (eds). Springer, Boston, MA, pp623-629, 1996. | |
Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, et al: TRIBE-AKI Consortium: Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol. 22:1748–1757. 2011.PubMed/NCBI View Article : Google Scholar | |
Flora SJS, Pande M, Bhadauria S and Kannan GM: Combined administration of taurine and meso 2,3-dimercaptosuccinic acid in the treatment of chronic lead intoxication in rats. Hum Exp Toxicol. 23:157–166. 2004.PubMed/NCBI View Article : Google Scholar | |
Bai J, Yao X, Jiang L, Zhang Q, Guan H, Liu S, Wu W, Qiu T, Gao N, Yang L, et al: Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway. Sci Rep. 6(27733)2016.PubMed/NCBI View Article : Google Scholar | |
Yeh YH, Lee YT, Hsieh YL and Hwang DF: Dietary taurine reduces zinc-induced toxicity in male Wistar rats. J Food Sci. 76:T90–T98. 2011.PubMed/NCBI View Article : Google Scholar | |
Roy A, Manna P and Sil PC: Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/ NF-kappaB and mitochondria dependent pathways. Free Radic Res. 43:995–1007. 2009.PubMed/NCBI View Article : Google Scholar | |
Bera AK, Rana T, Das S, Bhattacharya D, Pan D, Bandyopadhyay S and Das SK: Mitigation of arsenic-mediated renal oxidative stress in rat by Pleurotus florida lectin. Hum Exp Toxicol. 30:940–951. 2011.PubMed/NCBI View Article : Google Scholar | |
Zheng Y, Qu H, Wang D, Li S, Zhang C and Piao F: Protection of Taurine Against Arsenic-Induced DNA Damage of Mice Kidneys. Adv Exp Med Biol. 975:917–927. 2017.PubMed/NCBI View Article : Google Scholar | |
Ahmad MK, Khan AA, Ali SN and Mahmood R: Chemoprotective effect of taurine on potassium bromate-induced DNA damage, DNA-protein cross-linking and oxidative stress in rat intestine. PLoS One. 10(e0119137)2015.PubMed/NCBI View Article : Google Scholar | |
Das J, Ghosh J, Manna P and Sil PC: Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation. Toxicology. 269:24–34. 2010.PubMed/NCBI View Article : Google Scholar | |
Eldin AAK, Shaheen AA, Abd Elgawad HM and Shehata NI: Protective effect of taurine and quercetin against renal dysfunction associated with the combined use of gentamycin and diclofenac. Indian J Biochem Biophys. 45:332–340. 2008.PubMed/NCBI | |
Ma N, Kato T, Isogai T, Gu Y and Yamashita T: The Potential Effects of Taurine in Mitigation of Radiation Nephropathy. In: Taurine 11. Hu J, Piao F, Schaffer SW, El Idrissi A and Wu JY (eds). Springer Singapore, Singapore, pp497-505, 2019. | |
Ogino T, Than TA, Hosako M, Ozaki M, Omori M and Okada S: Taurine chloramine: A possible oxidant reservoir. Adv Exp Med Biol. 643:451–461. 2009.PubMed/NCBI View Article : Google Scholar | |
Kim C and Cha YN: Production of reactive oxygen and nitrogen species in phagocytes is regulated by taurine chloramine. Adv Exp Med Biol. 643:463–472. 2009.PubMed/NCBI View Article : Google Scholar | |
Trachtman H, Futterweit S, Prenner J and Hanon S: Antioxidants reverse the antiproliferative effect of high glucose and advanced glycosylation end products in cultured rat mesangial cells. Biochem Biophys Res Commun. 199:346–352. 1994.PubMed/NCBI View Article : Google Scholar | |
Stanton RC: Oxidative stress and diabetic kidney disease. Curr Diab Rep. 11:330–336. 2011.PubMed/NCBI View Article : Google Scholar | |
Dronavalli S, Duka I and Bakris GL: The pathogenesis of diabetic nephropathy. Nat Clin Pract Endocrinol Metab. 4:444–452. 2008.PubMed/NCBI View Article : Google Scholar | |
Goh SY and Cooper ME: Clinical review: The role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab. 93:1143–1152. 2008.PubMed/NCBI View Article : Google Scholar | |
Riser BL, Ladson-Wofford S, Sharba A, Cortes P, Drake K, Guerin CJ, Yee J, Choi ME, Segarini PR and Narins RG: TGF-β receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain. Kidney Int. 56:428–439. 1999.PubMed/NCBI View Article : Google Scholar | |
Kitada M, Ogura Y and Koya D: Rodent models of diabetic nephropathy: Their utility and limitations. Int J Nephrol Renovasc Dis. 9:279–290. 2016.PubMed/NCBI View Article : Google Scholar | |
Koya D, Hayashi K, Kitada M, Kashiwagi A, Kikkawa R and Haneda M: Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. J Am Soc Nephrol. 14 (Suppl 3):S250–S253. 2003.PubMed/NCBI View Article : Google Scholar | |
Lee EA, Seo JY, Jiang Z, Yu MR, Kwon MK, Ha H and Lee HB: Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney. Kidney Int. 67:1762–1771. 2005.PubMed/NCBI View Article : Google Scholar | |
Huang JS, Chuang LY, Guh JY, Huang YJ and Hsu MS: Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells. Am J Physiol Renal Physiol. 293:F1072–F1082. 2007.PubMed/NCBI View Article : Google Scholar | |
Huang JS, Chuang LY, Guh JY, Yang YL and Hsu MS: Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. Toxicol Appl Pharmacol. 233:220–226. 2008.PubMed/NCBI View Article : Google Scholar | |
Higo S, Miyata S, Jiang QY, Kitazawa R, Kitazawa S and Kasuga M: Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats. Kobe J Med Sci. 54:E35–E45. 2008.PubMed/NCBI | |
Park SH, Choi HJ, Lee JH, Woo CH, Kim JH and Han HJ: High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1. Kidney Int. 59:1695–1705. 2001.PubMed/NCBI View Article : Google Scholar | |
Huang JS, Chuang LY, Guh JY and Huang YJ: Effects of nitric oxide and antioxidants on advanced glycation end products-induced hypertrophic growth in human renal tubular cells. Toxicol Sci. 111:109–119. 2009.PubMed/NCBI View Article : Google Scholar | |
Yao HT, Lin P, Chang YW, Chen CT, Chiang MT, Chang L, Kuo YC, Tsai HT and Yeh TK: Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes. Food Chem Toxicol. 47:1703–1709. 2009.PubMed/NCBI View Article : Google Scholar | |
Pandya KG, Budhram R, Clark GJ and Lau-Cam CA: Taurine can enhance the protective actions of metformin against diabetes-induced alterations adversely affecting renal function. Adv Exp Med Biol. 803:227–250. 2015.PubMed/NCBI View Article : Google Scholar | |
Chen SW, Chen YX, Shi J, Lin Y and Xie WF: The restorative effect of taurine on experimental nonalcoholic steatohepatitis. Dig Dis Sci. 51:2225–2234. 2006.PubMed/NCBI View Article : Google Scholar | |
Miyazaki T, Karube M, Matsuzaki Y, Ikegami T, Doy M, Tanaka N and Bouscarel B: Taurine inhibits oxidative damage and prevents fibrosis in carbon tetrachloride-induced hepatic fibrosis. J Hepatol. 43:117–125. 2005.PubMed/NCBI View Article : Google Scholar | |
Schlöndorff D: Choosing the right mouse model for diabetic nephropathy. Kidney Int. 77:749–750. 2010.PubMed/NCBI View Article : Google Scholar | |
Perfumo F, Canepa A, Divino Filho JC, Nilsson E, Carrea A, Verrina E, Gusmano R and Bergström J: Muscle and plasma amino acids and nutritional status in kidney-transplanted children. Nephrol Dial Transplant. 9:1778–1785. 1994.PubMed/NCBI | |
Wingenfeld P, Minor T, Gehrmann U, Strübind S, Isselhard W and Michalk D: Hypoxic cellular deterioration and its prevention by the amino acid taurine in a transplantation model with renal tubular cells (LLC-PK1). In Vitro Cell Dev Biol Anim. 31:483–486. 1995.PubMed/NCBI View Article : Google Scholar | |
Michalk DV, Hoffmann B and Minor Th: Taurine Reduces Renal Ischemia/Reperfusion Injury in the Rat. In: Taurine 5. Lombardini JB, Schaffer SW and Azuma J (eds). Springer, Boston, MA, pp49-56, 2003. | |
Guz G, Oz E, Lortlar N, Ulusu NN, Nurlu N, Demirogullari B, Omeroglu S, Sert S and Karasu C: The effect of taurine on renal ischemia/reperfusion injury. Amino Acids. 32:405–411. 2007.PubMed/NCBI View Article : Google Scholar | |
Guan X, Dei-Anane G, Liang R, Gross ML, Nickkholgh A, Kern M, Ludwig J, Zeier M, Büchler MW, Schmidt J, et al: Donor preconditioning with taurine protects kidney grafts from injury after experimental transplantation. J Surg Res. 146:127–134. 2008.PubMed/NCBI View Article : Google Scholar |