Open Access

Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease

  • Authors:
    • Masaaki Kubota
    • Bo-Shi Zhang
    • Shu-Yang Li
    • Yoichi Yoshida
    • Hao Wang
    • Akihiko Adachi
    • Tomoo Matsutani
    • Seiichiro Mine
    • Toshio Machida
    • Ikuo Kamitsukasa
    • Takeshi Wada
    • Akiyo Aotsuka
    • Kenichiro Kitamura
    • Hirotaka Takizawa
    • Hideyuki Kuroda
    • Yasuo Iwadate
    • Takaki Hiwasa
  • View Affiliations

  • Published online on: December 21, 2022     https://doi.org/10.3892/mi.2022.64
  • Article Number: 4
  • Copyright : © Kubota et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Autoantibodies can be used in the early diagnosis and treatment of atherosclerosis‑related diseases. Using ProtoArray® screening of samples from patients with atherosclerosis, the present study identified thiosulfate sulfurtransferase‑like domain‑containing 2 (TSTD2) as a novel atherosclerosis antigen. The serum TSTD2 antibody levels were then quantified using an amplified luminescent proximity homogeneous assay‑linked immunosorbent assay. This demonstrated the levels of TSTD2 antibodies (TSTD2‑Abs) to be significantly higher in patients with acute cerebral infarction or chronic kidney disease than in healthy donors. The TSTD2‑Ab levels were also found to be higher in males, older adults, smokers, in those who consumed alcohol regularly, and in those with hypertension. Furthermore, Spearman's rank correlation analysis revealed TSTD2‑Ab levels to be strongly associated with measures of atherosclerosis severity, including plaque scores, intima‑media thickness of the carotid artery and the cardio‑ankle vascular index. Thus, TSTD2‑Abs may thus be a promising novel biomarker for atherosclerosis‑related cerebral infarction and kidney disease.
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Spandidos Publications style
Kubota M, Zhang B, Li S, Yoshida Y, Wang H, Adachi A, Matsutani T, Mine S, Machida T, Kamitsukasa I, Kamitsukasa I, et al: Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease. Med Int 3: 4, 2023.
APA
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A. ... Hiwasa, T. (2023). Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease. Medicine International, 3, 4. https://doi.org/10.3892/mi.2022.64
MLA
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A., Matsutani, T., Mine, S., Machida, T., Kamitsukasa, I., Wada, T., Aotsuka, A., Kitamura, K., Takizawa, H., Kuroda, H., Iwadate, Y., Hiwasa, T."Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease". Medicine International 3.1 (2023): 4.
Chicago
Kubota, M., Zhang, B., Li, S., Yoshida, Y., Wang, H., Adachi, A., Matsutani, T., Mine, S., Machida, T., Kamitsukasa, I., Wada, T., Aotsuka, A., Kitamura, K., Takizawa, H., Kuroda, H., Iwadate, Y., Hiwasa, T."Serum anti‑TSTD2 antibody as a biomarker for atherosclerosis‑induced ischemic stroke and chronic kidney disease". Medicine International 3, no. 1 (2023): 4. https://doi.org/10.3892/mi.2022.64