Open Access

Issues with the targeted therapy of non‑small cell lung cancer with thyroid metastases: A case report

  • Authors:
    • Ertugrul Bayram
    • Tugba Toyran
    • Burak Güney
    • Aysun Hatice Uguz
    • Derya Gümürdülü
    • Semra Paydas
  • View Affiliations

  • Published online on: October 17, 2023     https://doi.org/10.3892/mi.2023.117
  • Article Number: 57
  • Copyright : © Bayram et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Lung cancer is a common malignancy that has usually already metastasized at the time of diagnosis; however, thyroid metastases are extremely rare. Echinoderm microtubule‑associated protein‑like 4‑anaplastic lymphoma kinase (ALK) fusion has been observed in 3‑7% of cases of lung adenocarcinoma. ALK inhibitor therapy has been shown to exert a positive effect on disease progression. The present study describes the case of a patient with ALK‑positive non‑small cell lung carcinoma and thyroid metastases who exhibited a minimal response to ALK inhibitor therapy in the primary lesion, but had a complete pathological response in the thyroid, as confirmed by a thyroid biopsy. The present case report undermines the need for further evidence from genomic testing following this different tumor course in thyroid tissue.
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November-December 2023
Volume 3 Issue 6

Print ISSN: 2754-3242
Online ISSN:2754-1304

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Spandidos Publications style
Bayram E, Toyran T, Güney B, Uguz AH, Gümürdülü D and Paydas S: Issues with the targeted therapy of non‑small cell lung cancer with thyroid metastases: A case report. Med Int 3: 57, 2023
APA
Bayram, E., Toyran, T., Güney, B., Uguz, A.H., Gümürdülü, D., & Paydas, S. (2023). Issues with the targeted therapy of non‑small cell lung cancer with thyroid metastases: A case report. Medicine International, 3, 57. https://doi.org/10.3892/mi.2023.117
MLA
Bayram, E., Toyran, T., Güney, B., Uguz, A. H., Gümürdülü, D., Paydas, S."Issues with the targeted therapy of non‑small cell lung cancer with thyroid metastases: A case report". Medicine International 3.6 (2023): 57.
Chicago
Bayram, E., Toyran, T., Güney, B., Uguz, A. H., Gümürdülü, D., Paydas, S."Issues with the targeted therapy of non‑small cell lung cancer with thyroid metastases: A case report". Medicine International 3, no. 6 (2023): 57. https://doi.org/10.3892/mi.2023.117