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Comparison of the endoscopic endonasal to microscopic sublabial transsphenoidal approach in a case series of pituitary macroadenomas

  • Authors:
    • Stefanos Chatzidakis
    • Andreas Anagiotos
    • George Fotakopoulos
    • Vasiliki Epameinondas Georgakopoulou
    • Kyriakos Tarantinos
    • Petros Papalexis
    • Aikaterini Aravantinou‑Fatorou
    • Pagona Sklapani
    • Nikolaos Mathioudakis
    • Nikolaos Trakas
    • Demetrios A. Spandidos
    • Konstantinos Faropoulos

  • View Affiliations

  • Published online on: January 4, 2023     https://doi.org/10.3892/mi.2023.66
  • Article Number: 6

  • Copyright: © Chatzidakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

For a number of years, the microscopic sublabial transsphenoidal (MST) approach was considered the gold standard approach for the treatment of pituitary macroadenomas. Nonetheless, the trend is currently shifting away from the MST to the endonasal transsphenoidal (EET) approach. The aim of the present study was to examine the post‑operative outcomes of the first cases operated by a team of two young surgeons using the EET approach, compared to the cases operated by a team of senior neurosurgeons with extensive experience with the MST approach. For this purpose, data from 20 patients with pituitary adenoma were retrospectively collected from a single center who were operated by the current and previous pituitary‑surgery teams. All the patients who presented with visual impairment in the EET group recovered completely (5/5), whereas 4/5 patients in the MST group recovered completely. Primary hospitalization duration was similar in the two groups. Gross tumor removal was achieved in 90% of patients in the EET group compared to 70% of the patients operated with the MST technique. Intraoperative complications were comparable between the two groups. The first cases operated at the center with EET proved to have better visual outcomes and a larger tumor removal when compared to the MST group. A greater experience in using this technique could exponentiate the differences in the post‑operative outcomes, such as a lower hospitalization duration and fewer intraoperative complications. On the whole, colleagues who have yet to familiarize themselves with the EET approach could perhaps be encouraged to learn to utilize this technique, provided that their center is staffed with an experienced team of skull base surgeons to intervene in an intraoperative complication.
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January-February 2023
Volume 3 Issue 1

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Spandidos Publications style
Chatzidakis S, Anagiotos A, Fotakopoulos G, Georgakopoulou VE, Tarantinos K, Papalexis P, Aravantinou‑Fatorou A, Sklapani P, Mathioudakis N, Trakas N, Trakas N, et al: Comparison of the endoscopic endonasal to microscopic sublabial transsphenoidal approach in a case series of pituitary macroadenomas. Med Int 3: 6, 2023.
APA
Chatzidakis, S., Anagiotos, A., Fotakopoulos, G., Georgakopoulou, V.E., Tarantinos, K., Papalexis, P. ... Faropoulos, K. (2023). Comparison of the endoscopic endonasal to microscopic sublabial transsphenoidal approach in a case series of pituitary macroadenomas. Medicine International, 3, 6. https://doi.org/10.3892/mi.2023.66
MLA
Chatzidakis, S., Anagiotos, A., Fotakopoulos, G., Georgakopoulou, V. E., Tarantinos, K., Papalexis, P., Aravantinou‑Fatorou, A., Sklapani, P., Mathioudakis, N., Trakas, N., Spandidos, D. A., Faropoulos, K."Comparison of the endoscopic endonasal to microscopic sublabial transsphenoidal approach in a case series of pituitary macroadenomas". Medicine International 3.1 (2023): 6.
Chicago
Chatzidakis, S., Anagiotos, A., Fotakopoulos, G., Georgakopoulou, V. E., Tarantinos, K., Papalexis, P., Aravantinou‑Fatorou, A., Sklapani, P., Mathioudakis, N., Trakas, N., Spandidos, D. A., Faropoulos, K."Comparison of the endoscopic endonasal to microscopic sublabial transsphenoidal approach in a case series of pituitary macroadenomas". Medicine International 3, no. 1 (2023): 6. https://doi.org/10.3892/mi.2023.66