Open Access

Liver biopsy as a useful diagnostic tool for hepatic sarcoidosis: A case report

  • Authors:
    • Kenrei Uehara
    • Tatsuo Kanda
    • Shuhei Arima
    • Mai Totsuka
    • Masayuki Honda
    • Ryota Masuzaki
    • Reina Sasaki-Tanaka
    • Naoki Matsumoto
    • Masahiro Ogawa
    • Hirofumi Kogure
  • View Affiliations

  • Published online on: May 14, 2024     https://doi.org/10.3892/mi.2024.162
  • Article Number: 38
  • Copyright : © Uehara et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

In certain cases, it is difficult to distinguish hepatic sarcoidosis from malignant lymphoma or drug‑induced liver injury and to select the proper treatment for this condition. The present study describes the case of a female patient in her 30s who was referred to the hospital due to fever, arthralgia, myalgia and abnormal liver function test results for 4 months. A laboratory examination revealed elevated levels of serum angiotensin‑converting enzyme (ACE) and soluble interleukin‑2 receptor (sIL‑2R), as well as an increase in serum hepatic and biliary tract enzymes. Gallium scintigraphy revealed a marked uptake in the liver, as well as an uptake in the mediastinal, inguinal and external iliac lymph nodes. Magnetic resonance imaging revealed extensive hepatosplenomegaly with multiple non‑enhancing splenic nodules. Hepatic sarcoidosis was diagnosed by a liver biopsy as non‑caseating hepatic granulomas, and multinucleated giant cells were observed. The patient responded to treatment with 20 mg prednisolone daily, and exhibited an improvement in her symptoms. An improvement was also observed in her serum levels of ACE, sIL‑2R, and serum hepatic and biliary tract enzymes; decreased gallium uptake in the liver was also observed. On the whole, the present case report reconfirms that liver biopsy is a useful diagnostic tool for hepatic sarcoidosis.
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July-August 2024
Volume 4 Issue 4

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Spandidos Publications style
Uehara K, Kanda T, Arima S, Totsuka M, Honda M, Masuzaki R, Sasaki-Tanaka R, Matsumoto N, Ogawa M, Kogure H, Kogure H, et al: Liver biopsy as a useful diagnostic tool for hepatic sarcoidosis: A case report. Med Int 4: 38, 2024.
APA
Uehara, K., Kanda, T., Arima, S., Totsuka, M., Honda, M., Masuzaki, R. ... Kogure, H. (2024). Liver biopsy as a useful diagnostic tool for hepatic sarcoidosis: A case report. Medicine International, 4, 38. https://doi.org/10.3892/mi.2024.162
MLA
Uehara, K., Kanda, T., Arima, S., Totsuka, M., Honda, M., Masuzaki, R., Sasaki-Tanaka, R., Matsumoto, N., Ogawa, M., Kogure, H."Liver biopsy as a useful diagnostic tool for hepatic sarcoidosis: A case report". Medicine International 4.4 (2024): 38.
Chicago
Uehara, K., Kanda, T., Arima, S., Totsuka, M., Honda, M., Masuzaki, R., Sasaki-Tanaka, R., Matsumoto, N., Ogawa, M., Kogure, H."Liver biopsy as a useful diagnostic tool for hepatic sarcoidosis: A case report". Medicine International 4, no. 4 (2024): 38. https://doi.org/10.3892/mi.2024.162