Open Access

Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report

  • Authors:
    • Masahiro Manabe
    • Yuki Nagano
    • Takahiro Okuno
    • Takeshi Inoue
    • Ki-Ryang Koh
  • View Affiliations

  • Published online on: June 12, 2024     https://doi.org/10.3892/mi.2024.168
  • Article Number: 44
  • Copyright : © Manabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Methotrexate (MTX)‑related lymphoproliferative disease (LPD) is one of the most prominent late complications associated with MTX treatment. Although MTX‑related LPD exhibits a relatively high incidence of extranodal disease, the incidence of disease in a urinary bladder is very low. The present study reports the case of a patient with MTX‑related LPD involving a urinary bladder mass. A 75‑year‑old female patient, who had been receiving MTX for ~15 years, was referred to the hospital due to fever and hematuria. A computed tomography scan revealed the thickening of the urinary bladder wall, hydronephrosis and lymph node swelling. The histopathological findings of the urinary bladder mass resulted in a diagnosis of MTX‑related LPD. Although MTX withdrawal did not have any effect, the subsequent chemotherapy resulted in complete remission. Although MTX‑related LPD in the bladder is rare, it is pertinent to consider MTX‑related LPD when hematuria is observed during MTX therapy.
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July-August 2024
Volume 4 Issue 4

Print ISSN: 2754-3242
Online ISSN:2754-1304

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Spandidos Publications style
Manabe M, Nagano Y, Okuno T, Inoue T and Koh K: Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report. Med Int 4: 44, 2024
APA
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., & Koh, K. (2024). Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report. Medicine International, 4, 44. https://doi.org/10.3892/mi.2024.168
MLA
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., Koh, K."Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report". Medicine International 4.4 (2024): 44.
Chicago
Manabe, M., Nagano, Y., Okuno, T., Inoue, T., Koh, K."Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report". Medicine International 4, no. 4 (2024): 44. https://doi.org/10.3892/mi.2024.168