Association between polymorphisms of DNA repair genes and intracranial aneurysms: A systematic review and meta‑analysis

Montasr,Mohamed M.; Fotakopoulos,George; Georgakopoulou,Vasiliki Epameinondas; Fotakopoulou,Ourania; Trakas,Nikolaos; Sklapani,Pagona; Fountas,Kostas N.

doi:10.3892/mi.2024.183

Association between polymorphisms of DNA repair genes and intracranial aneurysms: A systematic review and meta‑analysis

Authors:
- Mohamed M. Montasr
- George Fotakopoulos
- Vasiliki Epameinondas Georgakopoulou
- Ourania Fotakopoulou
- Nikolaos Trakas
- Pagona Sklapani
- Kostas N. Fountas
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Affiliations: Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Pathophysiology, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Pediatrics, General Hospital of Zakynthos ‘Agios Dionysios’, 29100 Zakynthos, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece
Published online on: July 24, 2024 https://doi.org/10.3892/mi.2024.183
Article Number: 59
Copyright : © Montasr et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Intracranial aneurysms (IAs) are present in ~2% of the general population, and genetic factors cannot be excluded for the risk of their development. The gene factors that result in the changes in the vascular extracellular matrix (ECM) may also be a key reason for IAs being hereditary. The VCAN gene [also known as chondroitin sulfate proteoglycan 2 (CSPG2)] plays various roles in maintaining ECM functions. The present systematic review and meta‑analysis aimed to investigate all eligible articles involving IAs on the association with germ line SNPs of DNA repair genes (up to January, 2024). The total number of patients was 2,308 [987 cases (poor outcomes) and 1,321 controls (good outcomes)]. The results revealed that rs2287926 G/G genotype and G allele and rs251124 T/T genotype and minor allele T increased the risk of developing IAs. However, further studies are required to examine these gene polymorphisms as screening markers for IAs.

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