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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2008 Volume 1 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

c-Jun-mediated repression and transactivation of fibronectin

  • Authors:
    • Yukio Hayashi
    • Yuji Shino
    • Kengo Saito
    • Hideki Tanzawa
    • Hiroshi Shirasawa

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Virology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
  • Pages: 99-103
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/mmr.1.1.99
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Abstract

Fibronectin (FN) is transactivated by human papillomavirus type 16 (HPV16) E6 via the induction of c-Jun-ATF-2 complexes binding to the cyclic AMP response element (CRE) in the FN promoter. The present study analyzed c-Jun regulation of FN gene expression. Northern and immunoblot analyses showed that c-Jun expression was enhanced in HPV16-E6-expressing cells. However, mouse 10T1/2 cell lines overexpressing c-Jun showed an inverse correlation between the expression levels of c-Jun and those of FN. Luciferase assays indicated that the FN promoter was strongly repressed in c-Jun-overexpressing mouse 10T1/2 cells. Deletion and mutation analyses of the FN promoter revealed that repression of the FN promoter by c-Jun depends on the CRE located at -160 relative to the start site of transcription. Supershift assays of CRE-bound complexes from HPV16-E6-expressing and c-Jun-overexpressing cells suggested that the presence of ATF-2 in the complexes binding to CRE was required for the transactivation of the FN gene. Collectively, our study suggests that the FN gene can be either transactivated or repressed by c-Jun depending on the cell context.

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Copy and paste a formatted citation
Spandidos Publications style
Hayashi Y, Shino Y, Saito K, Tanzawa H and Shirasawa H: c-Jun-mediated repression and transactivation of fibronectin. Mol Med Rep 1: 99-103, 2008.
APA
Hayashi, Y., Shino, Y., Saito, K., Tanzawa, H., & Shirasawa, H. (2008). c-Jun-mediated repression and transactivation of fibronectin. Molecular Medicine Reports, 1, 99-103. https://doi.org/10.3892/mmr.1.1.99
MLA
Hayashi, Y., Shino, Y., Saito, K., Tanzawa, H., Shirasawa, H."c-Jun-mediated repression and transactivation of fibronectin". Molecular Medicine Reports 1.1 (2008): 99-103.
Chicago
Hayashi, Y., Shino, Y., Saito, K., Tanzawa, H., Shirasawa, H."c-Jun-mediated repression and transactivation of fibronectin". Molecular Medicine Reports 1, no. 1 (2008): 99-103. https://doi.org/10.3892/mmr.1.1.99
Copy and paste a formatted citation
x
Spandidos Publications style
Hayashi Y, Shino Y, Saito K, Tanzawa H and Shirasawa H: c-Jun-mediated repression and transactivation of fibronectin. Mol Med Rep 1: 99-103, 2008.
APA
Hayashi, Y., Shino, Y., Saito, K., Tanzawa, H., & Shirasawa, H. (2008). c-Jun-mediated repression and transactivation of fibronectin. Molecular Medicine Reports, 1, 99-103. https://doi.org/10.3892/mmr.1.1.99
MLA
Hayashi, Y., Shino, Y., Saito, K., Tanzawa, H., Shirasawa, H."c-Jun-mediated repression and transactivation of fibronectin". Molecular Medicine Reports 1.1 (2008): 99-103.
Chicago
Hayashi, Y., Shino, Y., Saito, K., Tanzawa, H., Shirasawa, H."c-Jun-mediated repression and transactivation of fibronectin". Molecular Medicine Reports 1, no. 1 (2008): 99-103. https://doi.org/10.3892/mmr.1.1.99
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