Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats

Zhong,Qing-Ling; Liu,Fan-Rong; Liu,De-Wu; Peng,Yan; Zhang,Xiang-Rong

doi:10.3892/mmr.2011.435

Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats

Authors:
- Qing-Ling Zhong
- Fan-Rong Liu
- De-Wu Liu
- Yan Peng
- Xiang-Rong Zhang
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Affiliations: Burns Institute, Nanchang University, Nanchang, P.R. China, Department of Pathology, Nanchang University Medical College, Nanchang, P.R. China, Center of Burn Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, P.R. China
Published online on: January 25, 2011 https://doi.org/10.3892/mmr.2011.435
Pages: 377-381

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Abstract

The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms invovled in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction of β-catenin and its downstream target in ESCs, cyclin D1, lead to poor wound healing in diabetes mellitus (DM). We found that, compared to the controls, the ESCs of diabetic rats were markedly reduced, the clone formation efficiency of the ESCs was markedly lower, and the mRNA and protein expression of β-catenin and cyclin D1 was significantly decreased. These findings suggest that the low expression of β-catenin and cyclin D1 may reduce the activity of ESCs from diabetic rats, which might be one of the important mechanisms of delayed wound healing in DM.