Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells

  • Authors:
    • Fan Zhang
    • Ling Xu
    • Xiujuan Qu
    • Mingfang Zhao
    • Bo Jin
    • Jian Kang
    • Yunpeng Liu
    • Xuejun Hu
  • View Affiliations

  • Published online on: July 20, 2011     https://doi.org/10.3892/mmr.2011.537
  • Pages: 1189-1193
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Abstract

β-Elemene, an anticancer agent, was isolated from the traditional Chinese medicine plant, curcuma aromatica. In this study, we investigated the synergistic antitumor effect of β-elemene and etoposide phosphate (VP-16) in A549 non-small cell lung carcinoma cells. The cells were treated with β-elemene (20 or 50 µg/ml), VP-16 (15 µg/ml) or the combination of both for 24 h. Compared to the treatment with β-elemene or VP-16 alone, an increased antitumor activity was observed with the combination of both, which was mediated by the cleavage of PARP, the up-regulation of Bax, p53 and p21, and the suppression of cyclin D1. These results suggest that the combination of β-elemene and VP-16 may be a promising therapeutic option for lung cancer.

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November-December 2011
Volume 4 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang F, Xu L, Qu X, Zhao M, Jin B, Kang J, Liu Y and Hu X: Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. Mol Med Rep 4: 1189-1193, 2011.
APA
Zhang, F., Xu, L., Qu, X., Zhao, M., Jin, B., Kang, J. ... Hu, X. (2011). Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. Molecular Medicine Reports, 4, 1189-1193. https://doi.org/10.3892/mmr.2011.537
MLA
Zhang, F., Xu, L., Qu, X., Zhao, M., Jin, B., Kang, J., Liu, Y., Hu, X."Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells". Molecular Medicine Reports 4.6 (2011): 1189-1193.
Chicago
Zhang, F., Xu, L., Qu, X., Zhao, M., Jin, B., Kang, J., Liu, Y., Hu, X."Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells". Molecular Medicine Reports 4, no. 6 (2011): 1189-1193. https://doi.org/10.3892/mmr.2011.537