BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (Review)

  • Authors:
    • Giulia Costanza Leonardi
    • Saverio Candido
    • Maurizio Carbone
    • Fabio Raiti
    • Valeria Colaianni
    • Sebastiano Garozzo
    • Diana Cinà
    • James A. McCubrey
    • Massimo Libra
  • View Affiliations

  • Published online on: August 2, 2012     https://doi.org/10.3892/mmr.2012.1016
  • Pages: 687-694
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Abstract

Papillary thyroid carcinoma (PTC) is the most common histotype among the thyroid cancer types. Although PTC is a curable malignancy, many patients relapse after treatment. Thus, there is a need to identify novel factors involved in the pathogenesis of PTC that may be used as targets for new therapies. The MAPK pathway has been implicated in the pathogenesis of PTC. Therefore, in this review, we summarize the role of the BRAF V600E mutation in the development and progression of thyroid cancer. The cinical implication of this molecular abnormality is also discussed. It is evident that the detection of the BRAF V600E mutation is crucial in order to identify novel avenues for thyroid cancer treatment.
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October 2012
Volume 6 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Leonardi GC, Candido S, Carbone M, Raiti F, Colaianni V, Garozzo S, Cinà D, McCubrey JA and Libra M: BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (Review). Mol Med Rep 6: 687-694, 2012.
APA
Leonardi, G.C., Candido, S., Carbone, M., Raiti, F., Colaianni, V., Garozzo, S. ... Libra, M. (2012). BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (Review). Molecular Medicine Reports, 6, 687-694. https://doi.org/10.3892/mmr.2012.1016
MLA
Leonardi, G. C., Candido, S., Carbone, M., Raiti, F., Colaianni, V., Garozzo, S., Cinà, D., McCubrey, J. A., Libra, M."BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (Review)". Molecular Medicine Reports 6.4 (2012): 687-694.
Chicago
Leonardi, G. C., Candido, S., Carbone, M., Raiti, F., Colaianni, V., Garozzo, S., Cinà, D., McCubrey, J. A., Libra, M."BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (Review)". Molecular Medicine Reports 6, no. 4 (2012): 687-694. https://doi.org/10.3892/mmr.2012.1016