Correlation of von Willebrand factor gene polymorphism and coronary heart disease

Xu,Ai-Guo; Xu,Rong-Mei; Lu,Chang-Qing; Yao,Meng-Ying; Zhao,Wei; Fu,Xin; Guo,Jing; Xu,Qin-Fu; Li,Dan-Dan

doi:10.3892/mmr.2012.1037

Correlation of von Willebrand factor gene polymorphism and coronary heart disease

Authors:
- Ai-Guo Xu
- Rong-Mei Xu
- Chang-Qing Lu
- Meng-Ying Yao
- Wei Zhao
- Xin Fu
- Jing Guo
- Qin-Fu Xu
- Dan-Dan Li
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Affiliations: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Human Science Laboratory, Institute of Physical Education of Henan Polytechnic University, Zhengzhou, Henan 454000, P.R. China, Department of Laboratory Medicine, The Second Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450052, P.R. China, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: August 16, 2012 https://doi.org/10.3892/mmr.2012.1037
Pages: 1107-1110

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Abstract

To characterize von Willebrand factor (vWF) gene polymorphisms at site A1381T and the correlation of plasma vWF levels with coronary heart disease, the vWF genotypes at site A1381T were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in patients diagnosed with coronary heart disease and normal controls (n=110 per group), and plasma vWF levels were measured by enzyme‑linked immunosorbent assay. The results showed that the plasma vWF levels were higher in the experimental group than in the control group and had no association with gender (t=11.69, p<0.05). In the experimental group, the plasma vWF levels were higher in the patients with the AG genotype than in those with the GG genotype (p<0.05). In the control group, the plasma vWF levels of the subjects with blood type O were significantly lower than those of the individuals with other blood types (p<0.05). In the experimental group, all blood types had significantly higher plasma vWF levels than the control group and the difference was significant among different blood types (p<0.05). In summary, vWF gene polymorphisms at site A1381T were not associated with coronary heart disease, but plasma vWF levels were influenced by vWF gene polymorphisms at site A1381T, blood type and coronary heart disease.

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1	Terraube V, O’Donnell JS and Jenkins PV: Factor VIII and von Willebrand factor interaction: biological, clinical and therapeutic importance. Haemophilia. 16:3–13. 2010. View Article : Google Scholar : PubMed/NCBI
2	Nair SC, Viswabandya A and Srivastava A: Diagnosis and management of von Willebrand disease: a developing country perspective. Semin Thromb Hemost. 37:587–594. 2011. View Article : Google Scholar : PubMed/NCBI
3	Othman M: Platelet-type von Willebrand disease: a rare, often misdiagnosed and underdiagnosed bleeding disorder. Semin Thromb Hemost. 37:464–469. 2011. View Article : Google Scholar : PubMed/NCBI
4	Bowen DJ and Collins PW: An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13. Blood. 103:941–947. 2004. View Article : Google Scholar : PubMed/NCBI
5	Szántó T, Schlammadinger A, Staelens S, et al: The A/T1381 polymorphism in the A1-domain of von Willebrand factor influences the affinity of von Willebrand factor for platelet glycoprotein Ibalpha. Thromb Haemost. 98:178–185. 2007.PubMed/NCBI
6	Simon D, Paludo CA, Ghisleni GC, Manfroi WC and Roisenberg I: Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease. Braz J Med Biol Res. 36:709–714. 2003. View Article : Google Scholar : PubMed/NCBI
7	van der Meer IM, Brouwers GJ, Bulk S, et al: Genetic variability of von Willebrand factor and risk of coronary heart disease: the Rotterdam Study. Br J Haematol. 124:343–347. 2004.PubMed/NCBI
8	Panda DK, Miao D, Bolivar I, et al: Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J Biol Chem. 279:16754–16766. 2004. View Article : Google Scholar
9	Klemm T, Mehnert AK, Siegemund A, et al: Impact of the Thr789Ala variant of the von Willebrand factor levels, on ristocetin co-factor and collagen binding capacity and its association with coronary heart disease in patients with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes. 113:568–572. 2005. View Article : Google Scholar : PubMed/NCBI
10	Sedding D, Daniel JM, Muhl L, et al: The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation. J Exp Med. 203:2801–2807. 2006. View Article : Google Scholar : PubMed/NCBI
11	Bray PF, Mathias RA, Faraday N, et al: Heritability of platelet function in families with premature coronary artery disease. J Thromb Haemost. 5:1617–1623. 2007. View Article : Google Scholar : PubMed/NCBI
12	Kumari M, Marmot M and Brunner E: Social determinants of von willebrand factor: the Whitehall II study. Arterioscler Thromb Vasc Biol. 20:1842–1847. 2000. View Article : Google Scholar : PubMed/NCBI
13	Hamaad A, Sosin MD, Blann AD, Lip GY and MacFadyen RJ: Markers of thrombosis and hemostasis in acute coronary syndromes: relationship to increased heart rate and reduced heart-rate variability. Clin Cardiol. 32:204–209. 2009. View Article : Google Scholar : PubMed/NCBI
14	Rios DR, Carvalho MG, Figueiredo RC, et al: ADAMTS13 and von Willebrand factor in patients undergoing hemodialysis. J Thromb Thrombolysis. Feb 2–2012.(Epub ahead of print).
15	Rios DR, Fernandes AP, Figueiredo RC, et al: Relationship between ABO blood groups and von Willebrand factor, ADAMTS13 and factor VIII in patients undergoing hemodialysis. J Thromb Thrombolysis. 33:416–421. 2012. View Article : Google Scholar : PubMed/NCBI