Adrenomedullin is involved in the progression of colonic adenocarcinoma

  • Authors:
    • Jee-Youn Kim
    • Won-Do Park
    • Sun Lee
    • Jae-Hoon Park
  • View Affiliations

  • Published online on: August 24, 2012     https://doi.org/10.3892/mmr.2012.1045
  • Pages: 1030-1034
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Abstract

Adrenomedullin (ADM), initially identified in human pheochromocytoma, participates in a wide range of physiological and pathological processes, including vasorelaxation, angiogenesis and apoptosis. Recent studies have reported that ADM protected tumor cells against apoptotic cell death via the upregulation of Bcl-2 or the activation of the phosphatidylinositol 3-kinase/Akt pathway. Several studies have also provided evidence that ADM is involved in tumor initiation and progression. However, this has not been shown in gastrointestinal tumors. To investigate the role of ADM in gastrointestinal tumor progression, we determined the expression levels of ADM in 72 cases of stomach cancer and 84 cases of colon cancer and determined whether there was an association between the ADM expression levels and pathological parameters or clinical survival rates. We found that the expression levels of ADM were significantly higher in colon cancers than in matching normal mucosal tissues. In addition, the expression levels of ADM in colon cancers were correlated with cancer stage and clinical survival rate. However, we did not find any significant correlations between ADM expression levels and clinical or pathological parameters in stomach cancers. Taken together, our data strongly suggest that ADM is involved in the progression of colon cancer.
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November 2012
Volume 6 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Kim J, Park W, Lee S and Park J: Adrenomedullin is involved in the progression of colonic adenocarcinoma. Mol Med Rep 6: 1030-1034, 2012.
APA
Kim, J., Park, W., Lee, S., & Park, J. (2012). Adrenomedullin is involved in the progression of colonic adenocarcinoma. Molecular Medicine Reports, 6, 1030-1034. https://doi.org/10.3892/mmr.2012.1045
MLA
Kim, J., Park, W., Lee, S., Park, J."Adrenomedullin is involved in the progression of colonic adenocarcinoma". Molecular Medicine Reports 6.5 (2012): 1030-1034.
Chicago
Kim, J., Park, W., Lee, S., Park, J."Adrenomedullin is involved in the progression of colonic adenocarcinoma". Molecular Medicine Reports 6, no. 5 (2012): 1030-1034. https://doi.org/10.3892/mmr.2012.1045