Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-κB‑mediated matrix metalloproteinase-9 expression

  • Authors:
    • Jie Qin
    • Yunbin Wang
    • Yu Bai
    • Kai Yang
    • Qiqi Mao
    • Yiwei  Lin
    • Debo Kong
    • Xiangyi Zheng
    • Liping Xie
  • View Affiliations

  • Published online on: August 30, 2012     https://doi.org/10.3892/mmr.2012.1054
  • Pages: 1040-1044
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Bladder cancer is the fourth most common cancer in males and the ninth most common in females. However, despite the numerous advances made in the past few decades, the prognosis of patients with bladder cancer remains poor. Metastasis is one of the major causes of mortality in bladder cancer patients. Therefore, the inhibition of metastasis is one of the most significant issues in bladder cancer research. The present study was conducted to evaluate the anti-metastatic potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) against bladder cancer and its mechanism of action. EGCG efficiently and dose-dependently inhibited adhesion, migration and invasion of T24 human bladder cancer cells. Mechanistically, EGCG inhibited phosphatidylinositol 3'-kinase/Akt activation that resulted in inactivation of nuclear factor-κB (NF-κB) and the inhibition of the expression of matrix metalloproteinase-9 (MMP-9), ultimately suppressing invasion and metastasis. These findings suggest that EGCG is a potential therapeutic candidate against tumor invasion.
View Figures
View References

Related Articles

Journal Cover

November 2012
Volume 6 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Qin J, Wang Y, Bai Y, Yang K, Mao Q, Lin Y, Kong D, Zheng X and Xie L: Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-κB‑mediated matrix metalloproteinase-9 expression. Mol Med Rep 6: 1040-1044, 2012
APA
Qin, J., Wang, Y., Bai, Y., Yang, K., Mao, Q., Lin, Y. ... Xie, L. (2012). Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-κB‑mediated matrix metalloproteinase-9 expression. Molecular Medicine Reports, 6, 1040-1044. https://doi.org/10.3892/mmr.2012.1054
MLA
Qin, J., Wang, Y., Bai, Y., Yang, K., Mao, Q., Lin, Y., Kong, D., Zheng, X., Xie, L."Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-κB‑mediated matrix metalloproteinase-9 expression". Molecular Medicine Reports 6.5 (2012): 1040-1044.
Chicago
Qin, J., Wang, Y., Bai, Y., Yang, K., Mao, Q., Lin, Y., Kong, D., Zheng, X., Xie, L."Epigallocatechin-3-gallate inhibits bladder cancer cell invasion via suppression of NF-κB‑mediated matrix metalloproteinase-9 expression". Molecular Medicine Reports 6, no. 5 (2012): 1040-1044. https://doi.org/10.3892/mmr.2012.1054