Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December 2012 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2012 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer

  • Authors:
    • Ting Feng
    • Jian-Hong Zhou
    • Jia Liu
    • Feng Ye
    • Weiguo Lu
    • Xing Xie
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, P.R. China, Central Laboratory, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, P.R. China
  • Pages: 1301-1304
    |
    Published online on: September 10, 2012
       https://doi.org/10.3892/mmr.2012.1068
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

The aim of this study was to investigate the role of the cell surface expression levels of HLA class I and II molecules, the costimulatory molecules CD80/B7-1 and CD86/B7-2, and the adhesion molecules CD54 and CD58 during cervical carcinogenesis. The expression levels of MHC class I and II molecules, the costimulatory molecules CD80/B7-1 and CD86/B7-2 and the adhesion molecules CD54 and CD58 on CD14+ peripheral blood monocytes (PBMs) from 21 cases of cervical intraepithelial neoplasia (CIN) II-III, 51 squamous cervical carcinomas (SCCs) and 18 healthy controls were analyzed using flow cytometry analysis. We found increased expression levels of HLA-DR (p=0.000), HLA-DQ (p=0.000), CD86/B7-2 (p=0.002) and CD58 (p=0.000) on PBMs from patients with SCC and CIN II-III, compared with healthy control subjects, whereas no significant difference existed in the expression levels of HLA class I antigens, HLA-DP CD80/B7-1 and CD54. Upregulated expression levels of HLA-DR, HLA-DQ, CD86/B7-2 and CD58 were associated with disease progression, indicating that an increased expression of HLA-DR, HLA-DQ, CD86/B7-2 and CD58 on PBMs may be correlated with the evolution of cervical cancer.
View Figures
View References

1 

Moore MA and Tajima K: Cervical cancer in the asian pacific-epidemiology, screening and treatment. Asian Pac J Cancer Prev. 5:349–361. 2004.PubMed/NCBI

2 

Walboomers JM, Jacobs MV, Manos MM, et al: Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 189:12–19. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Chouaib S, Asselin-Paturel C, Mami-Chouaib F, Caignard A and Blay JY: The host-tumor immune conflict: from immunosuppression to resistance and destruction. Immunol Today. 18:493–497. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Zhou JH, Ye F, Chen HZ, Zhou CY, Lu WG and Xie X: Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma. Life Sci. 78:2643–2649. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Huang AY, Golumbek P, Ahmadzadeh M, Jaffee E, Pardoll D and Levitsky H: Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science. 264:961–965. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Ardavin C, Martinez del Hoyo G, Martin P, et al: Origin and differentiation of dendritic cells. Trends Immunol. 22:691–700. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Fidler IJ and Kleinerman ES: Lymphokine-activated human blood monocytes destroy tumor cells but not normal cells under cocultivation conditions. J Clin Oncol. 2:937–943. 1984.

8 

Kleinerman ES, Ceccorulli LM, Bonvini E, Zicht R and Gallin JI: Lysis of tumor cells by human blood monocytes by a mechanism independent of activation of the oxidative burst. Cancer Res. 45:2058–2064. 1985.PubMed/NCBI

9 

Ditschkowski M, Kreuzfelder E, Rebmann V, et al: HLA-DR expression and soluble HLA-DR levels in septic patients after trauma. Ann Surg. 229:246–254. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Gabrilovich DI, Corak J, Ciernik IF, Kavanaugh D and Carbone DP: Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res. 3:483–490. 1997.PubMed/NCBI

11 

Pinzon-Charry A, Ho CS, Maxwell T, et al: Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer. Br J Cancer. 97:1251–1259. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Novellino PS, Trejo YG, Beviacqua M, Bordenave RH and Rumi LS: Cisplatin containing chemotherapy influences HLA-DR expression on monocytes from cancer patients. J Exp Clin Cancer Res. 18:481–484. 1999.PubMed/NCBI

13 

Novellino PS, Trejo YG, Beviacqua M, Bordenave RH and Rumi LS: Regulation of HLA-DR antigen in monocytes from colorectal cancer patients by in vitro treatment with human recombinant interferon-gamma. J Investig Allergol Clin Immunol. 10:90–93. 2000.PubMed/NCBI

14 

Woiciechowsky C, Asadullah K, Nestler D, et al: Diminished monocytic HLA-DR expression and ex vivo cytokine secretion capacity in patients with glioblastoma: effect of tumor extirpation. J Neuroimmunol. 84:164–171. 1998. View Article : Google Scholar : PubMed/NCBI

15 

van Bokhorst-De van der Schuer MA, von Blomberg-van der Flier BM, Riezebos RK, et al: Differences in immune status between well-nourished and malnourished head and neck cancer patients. Clin Nutr. 17:107–111. 1998.PubMed/NCBI

16 

Gebhard B, Gnant M, Schutz G, et al: Different transendothelial migration behaviour pattern of blood monocytes derived from patients with benign and malignant diseases of the breast. Anticancer Res. 20:4599–4604. 2000.PubMed/NCBI

17 

Matsuoka T, Tabata H and Matsushita S: Monocytes are differentially activated through HLA-DR, -DQ, and -DP molecules via mitogen-activated protein kinases. J Immunol. 166:2202–2208. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Becker JC, Czerny C and Brocker EB: Maintenance of clonal anergy by endogenously produced IL-10. Int Immunol. 6:1605–1612. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Wahl SM, McCartney-Francis N and Mergenhagen SE: Inflammatory and immunomodulatory roles of TGF-beta. Immunol Today. 10:258–261. 1989. View Article : Google Scholar : PubMed/NCBI

20 

Le Bouteiller P: HLA class I chromosomal region, genes, and products: facts and questions. Crit Rev Immunol. 14:89–129. 1994.PubMed/NCBI

21 

Van Gool SW, Vandenberghe P, de Boer M and Ceuppens JL: CD80, CD86 and CD40 provide accessory signals in a multiple-step T-cell activation model. Immunol Rev. 153:47–83. 1996.PubMed/NCBI

22 

Harding FA, McArthur JG, Gross JA, Raulet DH and Allison JP: CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature. 356:607–609. 1992. View Article : Google Scholar : PubMed/NCBI

23 

Girndt M, Sester M, Sester U, Kaul H and Kohler H: Defective expression of B7-2 (CD86) on monocytes of dialysis patients correlates to the uremia-associated immune defect. Kidney Int. 59:1382–1389. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Zhu DM, Dustin ML, Cairo CW, Thatte HS and Golan DE: Mechanisms of cellular avidity regulation in CD2-CD58-mediated T cell adhesion. ACS Chem Biol. 1:649–658. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Feng T, Zhou J, Liu J, Ye F, Lu W and Xie X: Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer. Mol Med Rep 6: 1301-1304, 2012.
APA
Feng, T., Zhou, J., Liu, J., Ye, F., Lu, W., & Xie, X. (2012). Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer. Molecular Medicine Reports, 6, 1301-1304. https://doi.org/10.3892/mmr.2012.1068
MLA
Feng, T., Zhou, J., Liu, J., Ye, F., Lu, W., Xie, X."Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer". Molecular Medicine Reports 6.6 (2012): 1301-1304.
Chicago
Feng, T., Zhou, J., Liu, J., Ye, F., Lu, W., Xie, X."Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer". Molecular Medicine Reports 6, no. 6 (2012): 1301-1304. https://doi.org/10.3892/mmr.2012.1068
Copy and paste a formatted citation
x
Spandidos Publications style
Feng T, Zhou J, Liu J, Ye F, Lu W and Xie X: Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer. Mol Med Rep 6: 1301-1304, 2012.
APA
Feng, T., Zhou, J., Liu, J., Ye, F., Lu, W., & Xie, X. (2012). Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer. Molecular Medicine Reports, 6, 1301-1304. https://doi.org/10.3892/mmr.2012.1068
MLA
Feng, T., Zhou, J., Liu, J., Ye, F., Lu, W., Xie, X."Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer". Molecular Medicine Reports 6.6 (2012): 1301-1304.
Chicago
Feng, T., Zhou, J., Liu, J., Ye, F., Lu, W., Xie, X."Altered expression levels of HLA class Ⅱ and costimulatory molecules on circulating monocytes from patients with cervical intraepithelial neoplasia and squamous cervical cancer". Molecular Medicine Reports 6, no. 6 (2012): 1301-1304. https://doi.org/10.3892/mmr.2012.1068
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team