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Molecular Medicine Reports
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December 2012 Volume 6 Issue 6

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Article

Protective effects of VEGF treatment on focal cerebral ischemia in rats

  • Authors:
    • Aimei Zhang
    • Lunan Liang
    • Huanfu Niu
    • Peng Xu
    • Yongnan Hao
  • View Affiliations / Copyright

    Affiliations: The Affiliated Hospital of Jining Medical College, Jining, Shandong 272029, P.R. China
  • Pages: 1315-1318
    |
    Published online on: September 10, 2012
       https://doi.org/10.3892/mmr.2012.1069
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Abstract

The aim of this study was to determine the effects of VEGF treatment on focal cerebral ischemia in rats. Rats were administered PBS or VEGF at concentrations of 10, 20 or 30 µg/ml. The effects of VEGF on the rat infarct volume and neurological deficits were investigated. Transmission electron microscopy was used to observe the ultrastructure of the cerebral cortex. Treatments with VEGF reduced the infarct volume and improved neurological functions. VEGF increased microvessel generation and also inhibited apoptosis in the cerebral cortex and basal ganglia. For the rats in the 30 µg/ml VEGF group, an even higher number of proliferative endothelial cells were observed by electron microscopy. In conclusion, VEGF treatment has protective effects on focal cerebral ischemia in rats.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang A, Liang L, Niu H, Xu P and Hao Y: Protective effects of VEGF treatment on focal cerebral ischemia in rats. Mol Med Rep 6: 1315-1318, 2012.
APA
Zhang, A., Liang, L., Niu, H., Xu, P., & Hao, Y. (2012). Protective effects of VEGF treatment on focal cerebral ischemia in rats. Molecular Medicine Reports, 6, 1315-1318. https://doi.org/10.3892/mmr.2012.1069
MLA
Zhang, A., Liang, L., Niu, H., Xu, P., Hao, Y."Protective effects of VEGF treatment on focal cerebral ischemia in rats". Molecular Medicine Reports 6.6 (2012): 1315-1318.
Chicago
Zhang, A., Liang, L., Niu, H., Xu, P., Hao, Y."Protective effects of VEGF treatment on focal cerebral ischemia in rats". Molecular Medicine Reports 6, no. 6 (2012): 1315-1318. https://doi.org/10.3892/mmr.2012.1069
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang A, Liang L, Niu H, Xu P and Hao Y: Protective effects of VEGF treatment on focal cerebral ischemia in rats. Mol Med Rep 6: 1315-1318, 2012.
APA
Zhang, A., Liang, L., Niu, H., Xu, P., & Hao, Y. (2012). Protective effects of VEGF treatment on focal cerebral ischemia in rats. Molecular Medicine Reports, 6, 1315-1318. https://doi.org/10.3892/mmr.2012.1069
MLA
Zhang, A., Liang, L., Niu, H., Xu, P., Hao, Y."Protective effects of VEGF treatment on focal cerebral ischemia in rats". Molecular Medicine Reports 6.6 (2012): 1315-1318.
Chicago
Zhang, A., Liang, L., Niu, H., Xu, P., Hao, Y."Protective effects of VEGF treatment on focal cerebral ischemia in rats". Molecular Medicine Reports 6, no. 6 (2012): 1315-1318. https://doi.org/10.3892/mmr.2012.1069
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