Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

  • Authors:
    • So-Jung Kim
    • Hyeong-Jin Kim
    • Hye-Ri Kim
    • Seung-Ho Lee
    • Sung-Dae Cho
    • Chang-Sun Choi
    • Jeong-Seok Nam
    • Ji-Youn Jung
  • View Affiliations

  • Published online on: September 17, 2012     https://doi.org/10.3892/mmr.2012.1085
  • Pages: 1443-1449
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Abstract

The purpose of this study was to determine the effects of baicalein and wogonin, which are compounds derived from the Chinese herb Scutellaria baicalensis, in suppressing the viability of HT-29 human colon cancer cells. Following treatment with baicalein or wogonin, several apoptotic events were observed, including DNA fragmentation, chromatin condensation and increased cell cycle arrest in the G1 phase. Baicalein and wogonin decreased Bcl-2 expression, whereas the expression of Bax was increased in a dose-dependent manner compared with the control. Furthermore, the induction of apoptosis was accompanied by an inactivation of phosphatidylinositol 3-kinase (PI3K)/Akt in a dose-dependent manner. The administration of baicalein to mice resulted in the inhibition of the growth of HT-29 xenografts without any toxicity following 5 weeks of treatment. The results indicated that baicalein induced apoptosis via Akt activation in a p53-dependent manner in the HT-29 colon cancer cells and that it may serve as a chemopreventive or therapeutic agent for HT-29 colon cancer.
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December 2012
Volume 6 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Kim S, Kim H, Kim H, Lee S, Cho S, Choi C, Nam J and Jung J: Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. Mol Med Rep 6: 1443-1449, 2012.
APA
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C. ... Jung, J. (2012). Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. Molecular Medicine Reports, 6, 1443-1449. https://doi.org/10.3892/mmr.2012.1085
MLA
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C., Nam, J., Jung, J."Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells". Molecular Medicine Reports 6.6 (2012): 1443-1449.
Chicago
Kim, S., Kim, H., Kim, H., Lee, S., Cho, S., Choi, C., Nam, J., Jung, J."Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells". Molecular Medicine Reports 6, no. 6 (2012): 1443-1449. https://doi.org/10.3892/mmr.2012.1085