Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines

  • Authors:
    • Hai-Ji Sun
    • Yun-Jian Liu
    • Na Li
    • Zhi-Yong Sun
    • Hai-Wang Zhao
    • Chen Wang
    • Hui Li
    • Fang-Ming Ma
    • Song-Mei Shi
    • Xiao-Qiu Xu
    • Zhe-Yu Chen
    • Shu-Hong Huang
  • View Affiliations

  • Published online on: September 20, 2012     https://doi.org/10.3892/mmr.2012.1094
  • Pages: 1276-1280
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Abstract

The novel member of the Rab family of GTPases, Rab23, is an essential negative regulator of the Sonic hedgehog (Shh) signaling pathway. Loss of function mutation of the Rab23 gene causes abnormal development of the neural tube in mice and in certain human congenital diseases. The aberrant overexpression of Rab23 has been associated with various diseases, such as gastric, hepatocellular and lung cancer. The exact function of Rab23 in hepatocellular carcinomas (HCCs), however, remains unknown. Previously, we reported the abnormal sublocalization of Rab23 in lung cancers. In the current study, we investigated the role of Rab23 in HCCs. We report the distinct sublocalization pattern of Rab23 in HCC cell lines. This difference depends on the GDP/GTP-binding form, and inhibition of the Rab23 cycle decreases the expression and nuclear localization of Gli1.
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December 2012
Volume 6 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Sun H, Liu Y, Li N, Sun Z, Zhao H, Wang C, Li H, Ma F, Shi S, Xu X, Xu X, et al: Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines. Mol Med Rep 6: 1276-1280, 2012.
APA
Sun, H., Liu, Y., Li, N., Sun, Z., Zhao, H., Wang, C. ... Huang, S. (2012). Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines. Molecular Medicine Reports, 6, 1276-1280. https://doi.org/10.3892/mmr.2012.1094
MLA
Sun, H., Liu, Y., Li, N., Sun, Z., Zhao, H., Wang, C., Li, H., Ma, F., Shi, S., Xu, X., Chen, Z., Huang, S."Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines". Molecular Medicine Reports 6.6 (2012): 1276-1280.
Chicago
Sun, H., Liu, Y., Li, N., Sun, Z., Zhao, H., Wang, C., Li, H., Ma, F., Shi, S., Xu, X., Chen, Z., Huang, S."Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines". Molecular Medicine Reports 6, no. 6 (2012): 1276-1280. https://doi.org/10.3892/mmr.2012.1094