Polymorphisms of the IL-18 promoter and bronchial asthma

Wu,Song-Quan; Liang,Wei; Wang,Guang-Li; Li,Ling-Yun; Wang,Dan-Li; Chen,Cong

doi:10.3892/mmr.2012.1098

December 2012 Volume 6 Issue 6

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December 2012 Volume 6 Issue 6

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Article

Polymorphisms of the IL-18 promoter and bronchial asthma

Authors:
- Song-Quan Wu
- Wei Liang
- Guang-Li Wang
- Ling-Yun Li
- Dan-Li Wang
- Cong Chen
View Affiliations / Copyright

Affiliations: Medical Department of Lishui University, Lishui, Zhejiang 323000, P.R. China, The People's Hospital of Lishui City, Lishui, Zhejiang 323000, P.R. China
Pages: 1385-1388
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Published online on: September 26, 2012

https://doi.org/10.3892/mmr.2012.1098
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Abstract

To study the association of polymorphisms of the IL-18 promoter (-607C/A and -137G/C) with bronchial asthma, 120 subjects with bronchial asthma were selected as the experimental group (49 cases with bronchial asthma and allergic rhinitis as experimental group 1 and 71 cases with bronchial asthma without allergic rhinitis as experimental group 2) and 120 healthy individuals were selected as the control group. A polymerase chain reaction sequence-specific primer (PCR-SSP) was used to identify the genotypic polymorphisms between the experimental and control groups. The results revealed that the frequencies of the CC, CA and AA genotypes at -607C/A in experimental group 1 were 18.37, 40.82 and 40.82%, respectively; these frequencies were 32.39, 54.92 and 12.68%, respectively, in experimental group 2. There was a statistically significant difference in the genotype distribution between experimental groups 1 and 2 (χ2=12.81; P<0.05). The allele frequencies of genotypes C and A were 38.78 and 61.22%, respectively, in experimental group 1 and 59.86 and 40.14%, respectively, in experimental group 2. The allele frequencies at -607C/A were significantly different between experimental groups 1 and 2 (χ2=10.32; P<0.05). Frequencies of genotypes GG, GC and CC at -137C/A in experimental group 1 were 48.98, 46.94 and 4.08%, respectively, and 80.28, 14.08 and 4.08% in experimental group 2 with significant difference (χ2=15.73, P<0.05). Allele frequencies of G and C in experimental group 1 were 72.45 and 27.55%, and 87.32 and 12.68% in experimental group 2 with statistically significant difference (χ2=8.42, P<0.05). In conclusion, polymorphisms of the IL-18 gene promoter at -607C/A and -137G/C were associated with allergic rhinitis in bronchial asthma, indicating that polymorphisms of the IL-18 gene promoter at -607C/A and -137G/C differentially affect the pathogenesis of asthma and allergic rhinitis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Polymorphisms of the IL-18 promoter and bronchial asthma

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