Assessment of the correlation between TIMP4 SNPs and schizophrenia and autism spectrum disorders

  • Authors:
    • Sung-Vin Yim
    • Su Kang Kim
    • Hae Jeong Park
    • Hye Sook Jeon
    • Byung Chul Jo
    • Won Sub Kang
    • Sang Min Lee
    • Jong Woo Kim
    • Joo-Ho Chung
  • View Affiliations

  • Published online on: December 3, 2012     https://doi.org/10.3892/mmr.2012.1221
  • Pages: 489-494
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Abstract

Tissue inhibitors of metalloproteinases (TIMPs) are involved in synaptic plasticity, neuronal cell differentiation and neuroprotection in the central nervous system. To investigate whether TIMP4 polymorphisms are associated with schizophrenia and autism spectrum disorders (ASDs), 480 patients (schizophrenia, n=287; ASDs, n=193) and 296 controls were enrolled. Clinical symptoms of schizophrenia and ASDs were assessed using the operation criteria checklist for psychotic illness (OPCRIT) and Childhood Autism Rating Scale (CARS), respectively. One promoter single nucleotide polymorphism (SNP; rs3755724, -55C/T) and one exonic SNP (rs17035945, 3'-untranslated region) were selected. SNPStats and SNPAnalyzer Pro programs were used to calculate odds ratios. Multiple logistic regression models were performed to analyze the genetic data. Based on the results, these two SNPs were not associated with schizophrenia and ASD. In the analysis of clinical features of schizophrenia, rs3755724 was nominally associated with schizophrenia with poor concentration (P=0.044 in the codominant2 model, P=0.041 in the log-additive model and P=0.043 in allele frequency). These results suggest that TIMP4 is not associated with the development of schizophrenia and ASD in the population studied.
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February 2013
Volume 7 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yim S, Kim SK, Park HJ, Jeon HS, Jo BC, Kang WS, Lee SM, Kim JW and Chung J: Assessment of the correlation between TIMP4 SNPs and schizophrenia and autism spectrum disorders. Mol Med Rep 7: 489-494, 2013.
APA
Yim, S., Kim, S.K., Park, H.J., Jeon, H.S., Jo, B.C., Kang, W.S. ... Chung, J. (2013). Assessment of the correlation between TIMP4 SNPs and schizophrenia and autism spectrum disorders. Molecular Medicine Reports, 7, 489-494. https://doi.org/10.3892/mmr.2012.1221
MLA
Yim, S., Kim, S. K., Park, H. J., Jeon, H. S., Jo, B. C., Kang, W. S., Lee, S. M., Kim, J. W., Chung, J."Assessment of the correlation between TIMP4 SNPs and schizophrenia and autism spectrum disorders". Molecular Medicine Reports 7.2 (2013): 489-494.
Chicago
Yim, S., Kim, S. K., Park, H. J., Jeon, H. S., Jo, B. C., Kang, W. S., Lee, S. M., Kim, J. W., Chung, J."Assessment of the correlation between TIMP4 SNPs and schizophrenia and autism spectrum disorders". Molecular Medicine Reports 7, no. 2 (2013): 489-494. https://doi.org/10.3892/mmr.2012.1221