Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis

Tang,Haikuo; Wu,Zhiyuan; Zhang,Jianping; Su,Bing

doi:10.3892/mmr.2012.1254

Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis

Authors:
- Haikuo Tang
- Zhiyuan Wu
- Jianping Zhang
- Bing Su
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Affiliations: Department of Oral and Maxicallifacial Surgery, The Affiliated Stomatology Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510055, P.R. China, Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, P.R. China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Biomedical Research Institute, Shenzhen‑PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China
Published online on: December 28, 2012 https://doi.org/10.3892/mmr.2012.1254
Pages: 761-766

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Abstract

Oral squamous cell carcinoma (OSCC) is a common and lethal malignancy. Thus, improvement in current knowledge of molecular changes associated with OSCC is urgently needed to explore novel avenues of diagnostics and treatment of this disease. While aberrant expression of long non‑coding RNAs (lncRNAs) has been functionally associated with certain types of cancer, including lung, breast and prostate carcinomas, their expression pattern and biological relevance in OSCC is currently unknown. In the present study, the relative abundance of a collection of lncRNAs in tissue or saliva samples from OSCC patients was investigated. It was shown that subsets of lncRNAs are expressed across non‑tumor, tumor and metastatic tissue samples. Some detected lncRNAs were shown to be aberrantly expressed in cases of oral cancer and metastasis. Moreover, whole saliva contained a detectable amount of some lncRNAs, which appeared to be potential markers for OSCC. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.

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