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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May 2012 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease

  • Authors:
    • Mao-Ping Chu
    • Dan Wang
    • Ying-Ying Zhang
    • Bao-Qing Li
    • Ai-Hua Zhou
    • Xi-Wen Chen
    • Yan Qian

  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Heart Center, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, P.R. China, Department of Laboratory Medicine, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, P.R. China, Experimental Animal Center, Wenzhou Medical College, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 1237-1240
    |
    Published online on: February 20, 2012
       https://doi.org/10.3892/mmr.2012.799
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Abstract

The aim of this study was to explore the effect of pachyman, a mushroom extract, on CD4+CD25+ regulatory T cells (Tregs), serum interleukin 4 (IL-4) and interferon γ (IFN-γ) levels in a mouse model of Kawasaki disease. Lactobacillus casei cell wall extract was diluted to 1 mg/ml in PBS and administered to mice by intraperitoneal injection to establish a model of Kawasaki disease. Sixty female mice were used in this study, 40 of which were randomly assigned to a model (normal saline by gavage, n=20) or experimental group (200 mg/kg/day pachyman by gavage, n=20). The remaining 20 mice were disease and treatment-free, and were used as the control group. Compared to the control mice, mice in the model group exhibited a significantly lower percentage of CD4+CD25+ Tregs and significantly higher serum IL-4 and IFN-γ levels (P<0.05). However, CD4+CD25+ Tregs significantly increased and IL-4 and IFN-γ levels significantly decreased in experimental mice following pachyman treatment (P<0.05). Further analysis showed a negative correlation between CD4+CD25+ Tregs and IL-4/IFN-γ levels (P<0.05). In conclusion, pachyman improves immune function in a mouse model of Kawasaki disease by upregulating CD4+CD25+ Tregs, which may inhibit the cytokine secretion of Th1 and Th2 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Chu M, Wang D, Zhang Y, Li B, Zhou A, Chen X and Qian Y: Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease. Mol Med Rep 5: 1237-1240, 2012.
APA
Chu, M., Wang, D., Zhang, Y., Li, B., Zhou, A., Chen, X., & Qian, Y. (2012). Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease. Molecular Medicine Reports, 5, 1237-1240. https://doi.org/10.3892/mmr.2012.799
MLA
Chu, M., Wang, D., Zhang, Y., Li, B., Zhou, A., Chen, X., Qian, Y."Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease". Molecular Medicine Reports 5.5 (2012): 1237-1240.
Chicago
Chu, M., Wang, D., Zhang, Y., Li, B., Zhou, A., Chen, X., Qian, Y."Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease". Molecular Medicine Reports 5, no. 5 (2012): 1237-1240. https://doi.org/10.3892/mmr.2012.799
Copy and paste a formatted citation
x
Spandidos Publications style
Chu M, Wang D, Zhang Y, Li B, Zhou A, Chen X and Qian Y: Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease. Mol Med Rep 5: 1237-1240, 2012.
APA
Chu, M., Wang, D., Zhang, Y., Li, B., Zhou, A., Chen, X., & Qian, Y. (2012). Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease. Molecular Medicine Reports, 5, 1237-1240. https://doi.org/10.3892/mmr.2012.799
MLA
Chu, M., Wang, D., Zhang, Y., Li, B., Zhou, A., Chen, X., Qian, Y."Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease". Molecular Medicine Reports 5.5 (2012): 1237-1240.
Chicago
Chu, M., Wang, D., Zhang, Y., Li, B., Zhou, A., Chen, X., Qian, Y."Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease". Molecular Medicine Reports 5, no. 5 (2012): 1237-1240. https://doi.org/10.3892/mmr.2012.799
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