Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer

  • Authors:
    • Juliana Oliveira
    • Aledson V. Felipe
    • Paula Y.J. Chang
    • Celia A.M. Pimenta
    • Tiago D. Silva
    • João Massud
    • Nora M. Forones
  • View Affiliations

  • Published online on: May 23, 2012     https://doi.org/10.3892/mmr.2012.926
  • Pages: 395-398
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Abstract

The multidrug resistance 1 (MDR1) gene encodes P-glycoprotein, which confers resistance to antineoplastic drugs, but also affects the kinetic disposition of certain drugs and carcinogens. The C3435T polymorphism of the MDR1 gene may influence the transport and excretion of carcinogens, increasing the risk of cancer. The aim of this study was to evaluate the association between this polymorphism and the risk of gastric cancer (GC). Ninety-eight patients with non-cardia GC and 203 healthy subjects participated in the study. DNA was extracted from leukocytes and the MDR1 polymorphism was analyzed using PCR-RFLP. Serology was performed by ELISA for the investigation of infection with Helicobacter pylori. No significant difference in the genotype (p=0.668) or allele (p=0.745) frequency of the C3435T polymorphism was observed between the GC and control groups. There was no association between the genotypes studied and the risk of GC in patients infected with H. pylori (p=0.662). Patient survival was not correlated with the genotypes studied (p=0.454). No correlation was observed between the C3435T polymorphism of the MDR1 gene and GC risk or prognosis in the population studied.
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August 2012
Volume 6 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Oliveira J, Felipe AV, Chang PY, Pimenta CA, Silva TD, Massud J and Forones NM: Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer. Mol Med Rep 6: 395-398, 2012.
APA
Oliveira, J., Felipe, A.V., Chang, P.Y., Pimenta, C.A., Silva, T.D., Massud, J., & Forones, N.M. (2012). Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer. Molecular Medicine Reports, 6, 395-398. https://doi.org/10.3892/mmr.2012.926
MLA
Oliveira, J., Felipe, A. V., Chang, P. Y., Pimenta, C. A., Silva, T. D., Massud, J., Forones, N. M."Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer". Molecular Medicine Reports 6.2 (2012): 395-398.
Chicago
Oliveira, J., Felipe, A. V., Chang, P. Y., Pimenta, C. A., Silva, T. D., Massud, J., Forones, N. M."Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer". Molecular Medicine Reports 6, no. 2 (2012): 395-398. https://doi.org/10.3892/mmr.2012.926