βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis

  • Authors:
    • Zhen Li
    • Zhifeng Miao
    • Guanghua Jin
    • Xiaoxia Li
    • Hongwu Li
    • Zhidong Lv
    • Hui-Mian Xu
  • View Affiliations

  • Published online on: June 15, 2012     https://doi.org/10.3892/mmr.2012.951
  • Pages: 558-564
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Abstract

βig-h3 is an extracellular matrix protein and its expression is highly induced by transforming growth factor (TGF-β). It has also been suggested to play an important role in the growth and invasion of colon and pancreatic cancers. In the present study, we demonstrated that βig-h3 is expressed in mesothelial cells, especially in patients with advanced gastric cancer. The positive rate of βig-h3 was significantly higher in cases with a more invasive and advanced serous-type, with visible peritoneal metastasis, and in peritoneal lavage cytological examination (PLC) (+) and peritoneal lavage fluid CEA mRNA(+) subgroups (p<0.05). Our study also showed that the expression of βig-h3 gradually increased with increasing TGF-β1 concentrations in vitro in a time-dependant manner. In addition, βig-h3 also induced human gastric carcinoma cell line (SGC-7901) cell adhesion in a dose-dependent manner and significantly increased cell migration and proliferation. The results suggest that βig-h3 expression in peritoneal mesothelial cells in gastric cancer patients is a marker of the biological behavior of gastric cancer and plays an important role in the process of peritoneal carcinomatosis.
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September 2012
Volume 6 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li Z, Miao Z, Jin G, Li X, Li H, Lv Z and Xu H: βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis. Mol Med Rep 6: 558-564, 2012.
APA
Li, Z., Miao, Z., Jin, G., Li, X., Li, H., Lv, Z., & Xu, H. (2012). βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis. Molecular Medicine Reports, 6, 558-564. https://doi.org/10.3892/mmr.2012.951
MLA
Li, Z., Miao, Z., Jin, G., Li, X., Li, H., Lv, Z., Xu, H."βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis". Molecular Medicine Reports 6.3 (2012): 558-564.
Chicago
Li, Z., Miao, Z., Jin, G., Li, X., Li, H., Lv, Z., Xu, H."βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis". Molecular Medicine Reports 6, no. 3 (2012): 558-564. https://doi.org/10.3892/mmr.2012.951