Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae

Lee,Mu  Hong; Choi,Hyun  Mi; Hahm,Dae-Hyun; Her,Erk; Yang,Hyung-In; Yoo,Myung  Chul; Kim,Kyoung  Soo

doi:10.3892/mmr.2012.989

Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae

Authors:
- Mu Hong Lee
- Hyun Mi Choi
- Dae-Hyun Hahm
- Erk Her
- Hyung-In Yang
- Myung Chul Yoo
- Kyoung Soo Kim
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Affiliations: East-West Bone and Joint Research Institute, Kyung Hee University, Seoul 134-727, Republic of Korea, Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul 130-701, Republic of Korea , Department of Immunology, School of Medicine, Konkuk University, Chungju 380-701, Republic of Korea, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul 134-727, Republic of Korea
Published online on: July 17, 2012 https://doi.org/10.3892/mmr.2012.989
Pages: 791-796

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Abstract

Taheebo, the purple inner bark of the Bignoniaceae tree Tabebuia avellanedae Lorentz ex Griseb, which is found in tropical rain forests in northeastern Brazil, has been used as a traditional medicine for various diseases for more than 1,500 years. In the current study, various animal models were used to demonstrate the analgesic and anti-inflammatory properties of its ethanolic extract, thereby investigating its potential as a therapeutic treatment for diseases with pain and inflammation. In the hot plate and writhing tests for the in vivo analgesic effect test of Taheebo, a 200 mg/kg dose of the extract induced a significant anti-nociceptive effect and increased the pain threshold by approximately 30% compared with the control. In vascular permeability and tetradecanoylphorbol acetate (TPA)‑, arachidonic acid- and carrageenan-induced paw edema tests for anti-inflammatory effects, treatment with 200 mg/kg Taheebo led to significant anti-inflammatory effects and inhibited inflammation by 30-50% compared with the control. At 100 mg/kg, the extract decreased the levels of pain and inflammation in all tested models, but the degree of inhibition was not statistically significant. The results suggest that the ethanolic extract of the inner bark of Tabebuia avellanedae has the potential to be developed as a therapeutic or supportive drug against diseases with accompanying pain and inflammation, including osteoarthritis.

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