Association between manganese superoxide dismutase gene polymorphism and breast cancer risk: A meta-analysis of 17,842 subjects

Liu,Geling; Sun,Guogui; Wang,Yadi; Wang,Dan; Hu,Wanning; Zhang,Jun

doi:10.3892/mmr.2012.998

Association between manganese superoxide dismutase gene polymorphism and breast cancer risk: A meta-analysis of 17,842 subjects

Authors:
- Geling Liu
- Guogui Sun
- Yadi Wang
- Dan Wang
- Wanning Hu
- Jun Zhang
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Affiliations: Department of Endocrinology (Section I), Tangshan Workers Hospital, Tangshan 063000, P.R. China, Department of Chemoradiation Therapy, Tangshan People's Hospital, Tangshan 063000, P.R. China, Department of Radiotherapy, The Military General Hospital of Beijing PLA, Beijing 100700, P.R. China, Department of Library, Hebei Medical University, Shijiazhuang 050017, P.R. China, Department of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, P.R. China
Published online on: July 20, 2012 https://doi.org/10.3892/mmr.2012.998
Pages: 797-804

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Abstract

The aim of this meta-analysis was to explore the association between the manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk, and to investigate the interaction of this gene polymorphism with known risk factors for breast cancer. Crude odds ratios (ORs) with 95% confidence intervals (CIs) for breast cancer risk associated with co-dominant models [valine/alanine (Val/Ala) vs. Val/Val, Ala/Ala vs. Val/Val], a dominant model (Val/Ala + Ala/Ala vs. Val/Val) and a recessive model (Ala/Ala vs. Val/Ala + Val/Val) were statistically estimated. This meta‑analysis included 8,102 breast cancer cases and 9,740 controls from 14 published case-control studies. The data revealed no significant association between the MnSOD polymorphism and the risk of developing breast cancer. However, upon subgroup analyses, the risk was significantly increased in premenopausal women with the dominant model of the MnSOD gene polymorphism (OR, 1.15; 95% CI, 1.01-1.31). Statistically significant increased risks were also identified in women with the MnSOD genotypes containing the Ala allele who had a tobacco smoking history (OR, 1.17; 95% CI, 1.02-1.34), a higher body mass index (OR, 1.26; 95% CI, 1.02-1.56) or who used oral contraceptives (OR, 1.98; 95% CI, 1.34-2.93). By contrast, there was no significant association between breast cancer risk and alcohol consumption and ethnicity. This meta‑analysis demonstrated no statistically significant association between the MnSOD gene polymorphism and breast cancer susceptibility, except in premenopausal women with certain unhealthy lifestyle habbits.

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