Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta‑analysis of 39 case‑control studies

  • Authors:
    • Guo‑Xiang Tian
    • Xian‑Tao Zeng
    • Xiao‑Bing Wang
    • Ling Zhang
    • Wei Zhang
    • Wan‑Lin Wei
  • View Affiliations

  • Published online on: January 30, 2013     https://doi.org/10.3892/mmr.2013.1301
  • Pages: 1310-1318
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent. The present meta‑analysis aimed to evaluate the precise result by searching the PubMed database and using 39 case‑control studies comprising 7489 cases and 7051 controls.Each study tested the association between the eNOS Glu298Asp polymorphism and CHD. A meta‑analysis was then conducted using the Comprehensive Meta Analysis 2.2 software to calculate the pooled odds ratios (ORs) of five genetic models with 95% confidence intervals (CIs). Publication bias was also explored. The meta‑analysis showed a significant association between the eNOS Glu298Asp polymorphism and CHD susceptibility for all the genetic models [Asp vs. Glu, OR 1.26, 95% CI 1.14‑1.40, P<0.001; Asp/Asp vs. Glu/Glu, OR 1.58, 95% CI 1.23‑2.02, P<0.001; Glu/Asp vs. Glu/Glu, OR 1.12, 95% CI 1.03‑1.22, P=0.001; (Glu/Asp+Asp/Asp) vs. Glu/Glu, OR 1.17, 95% CI 1.07‑1.27, P<0.001; Asp/Asp vs. (Glu/Glu+Glu/Asp), OR 1.59, 95% CI 1.25‑2.03, P<0.001]. Subgroup and sensitivity analyses indicated that the result was robust. A weak publication bias was detected. The results indicated that the eNOS Glu298Asp polymorphism is a risk factor for developing CHD, particularly in the Asian population.
View Figures
View References

Related Articles

Journal Cover

April 2013
Volume 7 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tian GX, Zeng XT, Wang XB, Zhang L, Zhang W and Wei WL: Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta‑analysis of 39 case‑control studies. Mol Med Rep 7: 1310-1318, 2013.
APA
Tian, G., Zeng, X., Wang, X., Zhang, L., Zhang, W., & Wei, W. (2013). Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta‑analysis of 39 case‑control studies. Molecular Medicine Reports, 7, 1310-1318. https://doi.org/10.3892/mmr.2013.1301
MLA
Tian, G., Zeng, X., Wang, X., Zhang, L., Zhang, W., Wei, W."Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta‑analysis of 39 case‑control studies". Molecular Medicine Reports 7.4 (2013): 1310-1318.
Chicago
Tian, G., Zeng, X., Wang, X., Zhang, L., Zhang, W., Wei, W."Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta‑analysis of 39 case‑control studies". Molecular Medicine Reports 7, no. 4 (2013): 1310-1318. https://doi.org/10.3892/mmr.2013.1301