Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells

  • Authors:
    • Hong Li
    • Juan Mo
    • Guizhi Jia
    • Chao Liu
    • Zhidong Luan
    • Yifu Guan
  • View Affiliations

  • Published online on: April 3, 2013     https://doi.org/10.3892/mmr.2013.1412
  • Pages: 1751-1756
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Abstract

Notch and Wnt signaling play critical roles in the regulation of development and diseases. Several studies have previously reported that Notch may be a therapeutic target in the treatment of various types of human cancer. In this study, we report that activation of Notch1 inhibits the proliferation of BGC-823 gastric cancer cells. However, the activation of the Wnt/β‑catenin signaling pathway promotes the growth of BGC-823 cells. Furthermore, the combinational activation of the two signaling pathways promotes the proliferation of BGC-823 cells. These data suggest that the activation of Wnt signaling overcomes the pro-apoptotic role of Notch in BGC-823 gastric cancer cells.
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June 2013
Volume 7 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li H, Mo J, Jia G, Liu C, Luan Z and Guan Y: Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells. Mol Med Rep 7: 1751-1756, 2013
APA
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., & Guan, Y. (2013). Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells. Molecular Medicine Reports, 7, 1751-1756. https://doi.org/10.3892/mmr.2013.1412
MLA
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., Guan, Y."Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells". Molecular Medicine Reports 7.6 (2013): 1751-1756.
Chicago
Li, H., Mo, J., Jia, G., Liu, C., Luan, Z., Guan, Y."Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells". Molecular Medicine Reports 7, no. 6 (2013): 1751-1756. https://doi.org/10.3892/mmr.2013.1412