Increased leukocyte Rho-kinase activity in a population with acute coronary syndrome

  • Authors:
    • Hong-Wei Hou
    • Xu-Guang Li
    • Min Yan
    • Zheng-Qing Hu
    • Yu-E Song
  • View Affiliations

  • Published online on: May 8, 2013     https://doi.org/10.3892/mmr.2013.1463
  • Pages: 250-254
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Accumulating evidence suggests that Rho-associated kinase (ROCK) may be important in the pathogenesis of atherosclerosis and coronary vasospasm. In the present study, we investigated whether ROCK activity is increased in acute coronary syndrome (ACS) patients. Twenty-one patients with ACS (12 males, mean age 58.0±8.0 years) and 20 control subjects (10 males, mean age 55.0±6.0 years) were enrolled. Blood samples were obtained and demographics were recorded. Peripheral leukocyte ROCK activity was determined by the ratio of phospho-myosin‑binding subunit (P-MBS) on myosin light-chain phosphatase to total MBS. Compared with the control subjects, ROCK activity was significantly increased in ACS patients (0.69±0.07 vs. 0.45±0.04, P<0.001). There was no apparent correlation between the lipid levels (total cholesterol and low-density lipoprotein) and ROCK activity (r=0.17, P>0.05; r=0.08, P>0.05; respectively). However, ROCK activity correlated with mean arterial pressure (r=0.58; P<0.01). ROCK activity is increased in ACS patients indicating that this may be a novel serological marker of ACS.
View Figures
View References

Related Articles

Journal Cover

July 2013
Volume 8 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hou H, Li X, Yan M, Hu Z and Song Y: Increased leukocyte Rho-kinase activity in a population with acute coronary syndrome. Mol Med Rep 8: 250-254, 2013
APA
Hou, H., Li, X., Yan, M., Hu, Z., & Song, Y. (2013). Increased leukocyte Rho-kinase activity in a population with acute coronary syndrome. Molecular Medicine Reports, 8, 250-254. https://doi.org/10.3892/mmr.2013.1463
MLA
Hou, H., Li, X., Yan, M., Hu, Z., Song, Y."Increased leukocyte Rho-kinase activity in a population with acute coronary syndrome". Molecular Medicine Reports 8.1 (2013): 250-254.
Chicago
Hou, H., Li, X., Yan, M., Hu, Z., Song, Y."Increased leukocyte Rho-kinase activity in a population with acute coronary syndrome". Molecular Medicine Reports 8, no. 1 (2013): 250-254. https://doi.org/10.3892/mmr.2013.1463