Association of forkhead box J3 (FOXJ3) polymorphisms with rheumatoid arthritis

Ban,Ju  Yeon; Park,Hae  Jeong; Kim,Su  Kang; Kim,Jong  Woo; Lee,Yeon‑Ah; Choi,In‑Ah; Chung,Joo‑Ho; Hong,Seung‑Jae

doi:10.3892/mmr.2013.1623

Association of forkhead box J3 (FOXJ3) polymorphisms with rheumatoid arthritis

Authors:
- Ju Yeon Ban
- Hae Jeong Park
- Su Kang Kim
- Jong Woo Kim
- Yeon‑Ah Lee
- In‑Ah Choi
- Joo‑Ho Chung
- Seung‑Jae Hong
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Affiliations: College of Dentistry and Institute of Tissue Regeneration Engineering, Dankook University, Cheonan 330714, Republic of Korea, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130702, Republic of Korea, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul 130702, Republic of Korea, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Chung-Buk National University, Cheongju 361711, Republic of Korea
Published online on: August 9, 2013 https://doi.org/10.3892/mmr.2013.1623
Pages: 1235-1241

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Abstract

The aim of this study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of the forkhead box J3 (FOXJ3) gene and rheumatoid arthritis (RA). For the association studies, 307 patients with RA and 476 control patients without RA were recruited. Eleven SNPs (rs2282404, rs2455084, rs1393009, rs7539485, rs4660616, rs510157, rs343386, rs12732892, rs343389, rs343376 and rs585320) were genotyped using direct sequencing and the resulting data were analyzed using the SNPStats, Haploview and Helixtree programs. Seven SNPs (rs2455084, rs1393009, rs7539485, rs4660616, rs510157, rs343386 and rs343389) were associated with RA in three alternative models (log‑additive, dominant and recessive models; P<0.05). A strong linkage disequilibrium block, including all 11 SNPs, was constructed using the Gabriel method. Two haplotypes, TCCTTGTCTTT and TCTTCTGTCAC, were significantly associated with RA (P<0.05). In clinical characteristic analysis, the SNP rs585320 was also associated with the anti‑cyclic citrullinated peptide. These results suggest that FOXJ3 may be associated with the development of RA.

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