Radiotherapy‑induced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation

Wang,Huiyong; Zhang,Yanqing; Qian,Jiang; Zhang,Mingui; Wang,Xiangning

doi:10.3892/mmr.2013.1636

Radiotherapy‑induced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation

Authors:
- Huiyong Wang
- Yanqing Zhang
- Jiang Qian
- Mingui Zhang
- Xiangning Wang
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Affiliations: Department of Plastic Surgery, Shanghai Xi Mei Aesthetic and Plastic Center, Shanghai 200031, P.R. China, Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, P.R. China
Published online on: August 16, 2013 https://doi.org/10.3892/mmr.2013.1636
Pages: 1049-1054

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Abstract

Radiotherapy‑induced lacrimal gland injury is a serious clinical problem currently lacking satisfactory therapeutic strategies. Exploring the mechanisms underlying secondary injuries caused by radiation may aid in the development of novel targeted medicine. In the current study, growth arrest and DNA damage‑inducible 45 α (Gadd45a), a gene which is upregulated in irradiated skin, was observed as being overexpressed in the irradiated lacrimal gland. Moreover, overexpressed Gadd45a may impair lacrimal gland repair by inhibiting lacrimal gland epithelial cell migration and proliferation. Further signalling pathway analyses indicated that Gadd45a overexpression suppresses Akt (protein kinase B, PKB), P38 and JNK phosphorylation. Thus, the results of the current study suggested that Gadd45a may be a therapeutic target in radiation‑induced lacrimal gland injury.

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