Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model

  • Authors:
    • Yu-Yin Xu
    • Li Chen
    • Jia-Ming Zhou
    • Yuan-Yuan Wu
    • Yuan-Yuan Zhu
  • View Affiliations

  • Published online on: August 19, 2013     https://doi.org/10.3892/mmr.2013.1646
  • Pages: 1037-1042
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor. Studies have demonstrated that the toll‑like receptor 3 (TLR3)/interferon pathway is inhibitory in cancer cell proliferation, suggesting that the activation of this pathway may have therapeutic potential. In the present study, the inhibitory effects of BM‑06, a double‑stranded (ds)RNA TLR3 agonist, against HCC were studied in vivo. Using a 2‑acetylaminofluorene-induced HCC rat model, histological examination and analysis of corresponding biomarkers following treatment with BM-06, showed a decrease in tumor growth and cell proliferation, and an increase in apoptosis compared with that in a phosphate‑buffered saline control group. In addition, the observed antitumor effect of BM‑06 in the HCC rat model was demonstrated to be superior to the known TLR3 agonist, polyinosinic-polycytidylic acid.
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October 2013
Volume 8 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Xu Y, Chen L, Zhou J, Wu Y and Zhu Y: Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model. Mol Med Rep 8: 1037-1042, 2013
APA
Xu, Y., Chen, L., Zhou, J., Wu, Y., & Zhu, Y. (2013). Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model. Molecular Medicine Reports, 8, 1037-1042. https://doi.org/10.3892/mmr.2013.1646
MLA
Xu, Y., Chen, L., Zhou, J., Wu, Y., Zhu, Y."Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model". Molecular Medicine Reports 8.4 (2013): 1037-1042.
Chicago
Xu, Y., Chen, L., Zhou, J., Wu, Y., Zhu, Y."Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model". Molecular Medicine Reports 8, no. 4 (2013): 1037-1042. https://doi.org/10.3892/mmr.2013.1646